ID A0A3S4SS99_9ACTO Unreviewed; 497 AA.
AC A0A3S4SS99;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Sensor histidine kinase desK {ECO:0000313|EMBL:VEG73805.1};
DE EC=2.7.13.3 {ECO:0000313|EMBL:VEG73805.1};
GN Name=desK_2 {ECO:0000313|EMBL:VEG73805.1};
GN ORFNames=NCTC11923_00417 {ECO:0000313|EMBL:VEG73805.1};
OS Actinomyces slackii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=52774 {ECO:0000313|EMBL:VEG73805.1, ECO:0000313|Proteomes:UP000276899};
RN [1] {ECO:0000313|EMBL:VEG73805.1, ECO:0000313|Proteomes:UP000276899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11923 {ECO:0000313|EMBL:VEG73805.1,
RC ECO:0000313|Proteomes:UP000276899};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LR134363; VEG73805.1; -; Genomic_DNA.
DR RefSeq; WP_051281288.1; NZ_LR134363.1.
DR AlphaFoldDB; A0A3S4SS99; -.
DR STRING; 1278298.GCA_000428685_02435; -.
DR KEGG; asla:NCTC11923_00417; -.
DR Proteomes; UP000276899; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:VEG73805.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000276899};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:VEG73805.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 23..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 76..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 203..268
FT /note="Signal transduction histidine kinase subgroup 3
FT dimerisation and phosphoacceptor"
FT /evidence="ECO:0000259|Pfam:PF07730"
FT DOMAIN 371..462
FT /note="Histidine kinase/HSP90-like ATPase"
FT /evidence="ECO:0000259|Pfam:PF02518"
FT REGION 307..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 50566 MW; DDF5BADA6BA292E5 CRC64;
MAGTQQIDGQ VGPAPMRARR RPGALDLIAA VLVVYLSALN SPDPVASLDP QAARAIYIGL
LVVCALAIAG RRVAPLAAVI AIGLAMMGHL AAFSQLSLLA VAATLVAVET TQSRLDPPWR
WVMLGAAALG TAAASVRMVE LVGPEVPLRS FILVSVSWLV MAVAAFTGAW RRYGRNRVEQ
ALERAAVLEA QQATERRLAV VEERQRIARD VHDLLGHSLS VIGMQAEGAR AVLAVDAQAA
DDALAVIGDT ARRSVDEVRV LVDVLRADAP GQGAPTTAGG LVRGAGLAAD ARPVADQPAA
DVAAVPGHPL AAPRHGSEGD SPGNAASPHA APEAGQDSVE ALVRRARRAG QRVDLHLAIA
EDIPDLVDIV LLRAVQEALT NALRHAPGAA VRVELTARDG LAELSVVNGA PASRTPSATA
SPARRGFGLV AMRERVEAAG GGLVAGPEPD GGWLMRATLP LAPAPGGPTA AHSPGAGCPP
GGPAASLAAP TTAHAGA
//
