ID A0A3S4TD64_9ACTO Unreviewed; 717 AA.
AC A0A3S4TD64;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203,
GN ECO:0000313|EMBL:VEG75157.1};
GN ORFNames=NCTC11923_01815 {ECO:0000313|EMBL:VEG75157.1};
OS Actinomyces slackii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=52774 {ECO:0000313|EMBL:VEG75157.1, ECO:0000313|Proteomes:UP000276899};
RN [1] {ECO:0000313|EMBL:VEG75157.1, ECO:0000313|Proteomes:UP000276899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11923 {ECO:0000313|EMBL:VEG75157.1,
RC ECO:0000313|Proteomes:UP000276899};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; LR134363; VEG75157.1; -; Genomic_DNA.
DR RefSeq; WP_026427198.1; NZ_LR134363.1.
DR AlphaFoldDB; A0A3S4TD64; -.
DR STRING; 1278298.GCA_000428685_02233; -.
DR KEGG; asla:NCTC11923_01815; -.
DR Proteomes; UP000276899; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00203};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00203};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881, ECO:0000256|HAMAP-
KW Rule:MF_00203}; Reference proteome {ECO:0000313|Proteomes:UP000276899};
KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203}.
FT DOMAIN 16..95
FT /note="GIY-YIG"
FT /evidence="ECO:0000259|PROSITE:PS50164"
FT DOMAIN 208..243
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT DOMAIN 259..593
FT /note="UvrC family homology region profile"
FT /evidence="ECO:0000259|PROSITE:PS50165"
FT REGION 316..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 77518 MW; E438EC18688369E0 CRC64;
MADPSTYRPA PGEIPTSPGV YRFLDAQGRV IYVGKAKSLR ARLSSYFQDL AALHPRTQRM
VTTACAVEWT VVSTEVEALA LEYSWIKEFD PRFNVMFKDD KSYPYLAVTM QEEIPRAQVM
RGARRAGARY FGPFVAAWSI RETLDQLLRV FPVRSCSTGV LNRARSSGRP CLLGYIDKCS
APCVGRISPE DHRAIAEDLC SFMAGRTGPY LREVESQMKA ASAALDFERA ARLRDDAAAL
RKVIEGNAVV LPDATDADVF ALVRDELEAA VQVFHVRGGR VRGQRGWVLD LADDADDAEL
IERLLEQVYS ALVDPADEAG AGRGPSAPAS GPTTSLGVGQ SHHARALPRA GAPDAPAARE
GDAAATSVDD VAHTATTAVP REILVPVLPA NAATITAWLR QLRGGAVSLR VPLRGDKASL
MSTVRRNAEE ALRLHKTRRA GDLTQRAQAL EELAEALDLP EAPLRVECYD ISHTQGSHQV
GSMVVFEDGA PRKSDYRRFI IRGPQGEGAA DDTAAMHEVL TRRFKRLIAE QGRDTSAVSA
DQAAEEIEDA EGIAVASGPI DPTTGRARRF SYAPSLVVVD GGLPQVGAAQ AVLDELGVDV
PLIGLAKRLE EVWVPGDEFP IVLPRTSPAL YLLQHLRDES HRFAITHHRK KRTAGMTRSV
LDGVPGLGPA RQAALLREFG SVKRIRQATP DRLAQVKGIG PALAQAVLDH LNAEGSA
//
