ID A0A3S4UMI6_9ACTO Unreviewed; 948 AA.
AC A0A3S4UMI6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Calcium-transporting ATPase {ECO:0000313|EMBL:VEG74026.1};
DE EC=3.6.3.8 {ECO:0000313|EMBL:VEG74026.1};
GN Name=yloB {ECO:0000313|EMBL:VEG74026.1};
GN ORFNames=NCTC11923_00645 {ECO:0000313|EMBL:VEG74026.1};
OS Actinomyces slackii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=52774 {ECO:0000313|EMBL:VEG74026.1, ECO:0000313|Proteomes:UP000276899};
RN [1] {ECO:0000313|EMBL:VEG74026.1, ECO:0000313|Proteomes:UP000276899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11923 {ECO:0000313|EMBL:VEG74026.1,
RC ECO:0000313|Proteomes:UP000276899};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001836};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LR134363; VEG74026.1; -; Genomic_DNA.
DR RefSeq; WP_034514623.1; NZ_LR134363.1.
DR AlphaFoldDB; A0A3S4UMI6; -.
DR STRING; 1278298.GCA_000428685_00168; -.
DR KEGG; asla:NCTC11923_00645; -.
DR Proteomes; UP000276899; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR004014; ATPase_P-typ_cation-transptr_N.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR42861:SF29; SECRETORY PATHWAY CALCIUM ATPASE, ISOFORM G; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00690; Cation_ATPase_N; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SMART; SM00831; Cation_ATPase_N; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:VEG74026.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000276899};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 70..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..755
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 812..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 888..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..937
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..86
FT /note="Cation-transporting P-type ATPase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00831"
SQ SEQUENCE 948 AA; 99068 MW; FC34E8E434CFF8A0 CRC64;
MPITDTQADR TAPYARPAED VAAELSTDPA VGLSPAEAAR LLEEGGPNEL PSKPPVPAWK
RFIAQFNDPL VFLLLGAIVI SAIAWVLEGA HGAPVDSIVI LAVVTLNAIL GFVQENKAAD
AVAALSEMTR ATSTVLRDGS RVVVPSSELV VGDILVLGEG DQVGADARLL SAAALRVVES
SLTGEADAVT KTAEAVGPGT DLADRTCMVY RGTSVAQGTG RAIVVATGGD TEMGAIARML
DAVEEEATPL QEEIHQISKM LGIIVVVIAV VVVGTLLAMA EERSAETIIH ALLLGVSLAV
AAVPEGLPAI LSVVLALGVQ RMALHKAVVK KLTSVETLGS ASVICSDKTG TLTRSEMTIQ
EVVTASGLAV VTGIGYKPEG DVAPDADRDG QPDVDPLAGG LADEVTVVLS GGALASDAEL
SVTDDVWSVV GDPTEGAFLV AEKKLGTDGH REERFARAGE VPFTSDRKMM SVLHTDTKHG
MIIVSKGAPD VLMEHCAQVR VDGTAQELTE AIRGHFTEHI ADMSGRALRT LGVAYRVLDE
AEADRVRAEG ADADFSDMER DLVMAGVVGI IDPPRPEAAT AVAEAHRAGV RVLMITGDHP
ATAGRIAADL GIAERGARVV TGRELTEMDD DSLSAAVAEA SVYARVAPEH KMRIVHALKS
QGHTVSMTGD GVNDAPALRA ADIGVAMGIT GTQVTKEAAT MVLADDNFAT IVRAVGEGRR
IFDNIKKFLR FLLSSNMGEV LTVFGGVVLA GVIGLSGHSE TGVVLPLVAT QILWINLVTD
SGPALAMGVD PSVEDVMGRP PRKPTDRVVD GAMWGGVLLV GAVMAFSTLT TLDIFLPGGL
IEIGVSTDDL DTARTAAFTT LVFAQLFNTF NARSQTVSAF SHMFVNKWLW GSIALAVVLQ
IAVVEVPFLQ TAFSTSSLDA AHWMVVVAMA SLVLWVDEIR KLILRARG
//
