ID A0A3S8RZ58_9BACL Unreviewed; 787 AA.
AC A0A3S8RZ58;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=EIM92_20220 {ECO:0000313|EMBL:AZK48212.1};
OS Paenibacillus lentus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX NCBI_TaxID=1338368 {ECO:0000313|EMBL:AZK48212.1, ECO:0000313|Proteomes:UP000273145};
RN [1] {ECO:0000313|EMBL:AZK48212.1, ECO:0000313|Proteomes:UP000273145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25539 {ECO:0000313|EMBL:AZK48212.1,
RC ECO:0000313|Proteomes:UP000273145};
RA Kook J.-K., Park S.-N., Lim Y.K.;
RT "Genome sequencing of Paenibacillus lentus DSM25539(T).";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP034248; AZK48212.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S8RZ58; -.
DR KEGG; plen:EIM92_20220; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000273145; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR48378:SF2; SMR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Reference proteome {ECO:0000313|Proteomes:UP000273145}.
FT DOMAIN 712..787
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT REGION 616..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 522..599
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 334..341
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 787 AA; 87622 MW; 19D716F9548C022A CRC64;
MDEKILKTME YHKIIDMLVK YAQTSLGKMA AERLSPVSDL EEVKRLLQGT DEAFKVDRLK
GAPSFGGIVD IMPAVKRARI GGTLNPHELL GIATTLEGSR RVKRYISNIH EEEPVELLFT
LSDMLSEQKT LEDQIKRCID ESAEVLDSAS PELAQIRREL RGGEVRIREK LDAMIRSSSV
AKMLQDQLIT IRGDRFVIPV KAEYRSHFGG IVHDQSGSGA TLFIEPESIV AMNNKLRETR
LKEEREIEVI LQKLTALVGE QAELLGYDSD VLAQLDFIFA KARLAREMKS TLPRMNDRGF
LKLKKGRHPL IPADQVVPID VELGNQYTSI IVTGPNTGGK TVTLKTIGLL SLMAMSGLFV
PAEDGSQLCV FDAIYADIGD EQSIEQSLST FSSHMTNIIS ILRRMTAKSL VLLDEVGAGT
DPAEGSALAI AILEHIHSLG CRMVASTHYS ELKAYAYERK GVINASMEFD VNTLSPTYRL
LVGVPGRSNA FAIAERLGLS EQILEFARGE VKEEDLRVEH MIASLEENRL GAEQERETAE
RLRKELEEIR KRHEAELDKL ARERDKRIEK AEDEAIAIVA KARSEAERII DDLRKLALEE
GASVKEHKLI AARKELEEAE PKRKKTSPAR QATKAPRKIQ AGDEVMVYSL NQKGHVVELA
GSKEALVQLG IMKMKVSLDD LELIQAPSAA KTAQRIVTNV KRTRDDQVRS ELDLRGANLE
EALIEVDRFI DEAYLGNLGQ IYIIHGKGTG ILRTGISDYL RKHKHIKSYR LGNYGEGGTG
VTVAELK
//
