ID   A0A3S8W546_9ACTN        Unreviewed;       661 AA.
AC   A0A3S8W546;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Acetoacetate--CoA ligase {ECO:0000313|EMBL:AZM52051.1};
GN   ORFNames=DMA15_05155 {ECO:0000313|EMBL:AZM52051.1};
OS   Streptomyces sp. WAC 01529.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2203205 {ECO:0000313|EMBL:AZM52051.1, ECO:0000313|Proteomes:UP000269043};
RN   [1] {ECO:0000313|EMBL:AZM52051.1, ECO:0000313|Proteomes:UP000269043}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WAC 01529 {ECO:0000313|EMBL:AZM52051.1,
RC   ECO:0000313|Proteomes:UP000269043};
RA   Waglechner N., Wright G.D.;
RT   "Evolution of GPA BGCs.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP029617; AZM52051.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S8W546; -.
DR   OrthoDB; 9803968at2; -.
DR   Proteomes; UP000269043; Chromosome.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd05943; AACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AZM52051.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          42..98
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          108..478
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          545..620
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   661 AA;  72516 MW;  EE1C48EC910A5434 CRC64;
     MTSSANAAPL WQPSPERIAE AQITRFQAWA AERYGAPAEG GYEALHHWSV TDLEAFWKAV
     TDWFDVTFST PYARVLGDRS MPGAQWFPGS TLNYAEHALR AADDPARADT PALLHVDESH
     DPQPVTWAEL RRQVGSLAAE LRAMGVRPGD RVSGYLPNIP QAVVALLATA AVGAVWTSCA
     PDFGARSVLD RFQQVEPVVL FTVDGYRYGG KEHDRRDTVA ELRSELPGLR AVVHIPLLGT
     DAPEGALEWA ALTSADVAPV FEPVPFDHPL WVLYSSGTTG LPKAIVQSQG GILVEHLKQL
     GLHCDLGPDD RFFWYTSTGW MMWNFLVSGL LTGTTIVLYD GSPGHPDTAA QWRIAERTGA
     TLYGTSAAYV MACRKAGVHP ARDFDLSRVK CVATTGSPLP PDGFRWLHDE FAQTPGGLWT
     ASVSGGTDVC SCFAGAVPTL PVHIGELQAP CLGTDLQSWD PQGKPLIDEV GELVVTNPMP
     SMPIHFWNDP DGTRYHDSYF DTYPGVWRHG DWITRTSRGS VIIHGRSDST LNRQGVRMGS
     ADIYEAVERL PEIRESLVIG VEQPDGGYWM PLFVHLAPGA ALDDALRDRI KRTIREQLSP
     RHVPDEVIEV PGIPHTLTGK RIEVPVKRLL QGTPLNKAVN PGSVDNLDLL HFYEDLFRTR
     S
//