ID A0A3S8W5R6_9ACTN Unreviewed; 937 AA.
AC A0A3S8W5R6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=RNA helicase {ECO:0000313|EMBL:AZM52277.1};
GN ORFNames=DMA15_06440 {ECO:0000313|EMBL:AZM52277.1};
OS Streptomyces sp. WAC 01529.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2203205 {ECO:0000313|EMBL:AZM52277.1, ECO:0000313|Proteomes:UP000269043};
RN [1] {ECO:0000313|EMBL:AZM52277.1, ECO:0000313|Proteomes:UP000269043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 01529 {ECO:0000313|EMBL:AZM52277.1,
RC ECO:0000313|Proteomes:UP000269043};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP029617; AZM52277.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S8W5R6; -.
DR OrthoDB; 3229913at2; -.
DR Proteomes; UP000269043; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:AZM52277.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 44..202
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 324..487
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 652..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 937 AA; 104012 MW; EDBA5C6FBE11972B CRC64;
MTEDLSPAER YAAARKRAAE QATALASFRE MYEFGLDPFQ IEACQALEAG KGVLVAAPTG
SGKTIVGEFA VHLALLQGKK CFYTTPIKAL SNQKYADLSK RYGADKVGLL TGDNSVNSDA
PVVVMTTEVL RNMLYSGSQS LLNLGYVVMD EVHYLSDRFR GAVWEEVIIH LQESVTLVSL
SATVSNAEEF GDWLDTVRGD TEVIVSEHRP VPLFQHVLAG RRMYDLFEEG EGHKKAVNPD
LTRMARMEAS RAYNPRDRRK GKMVREADRE RERRQRSRIW TPGRPEVIER LDAEGLLPAI
TFIFSRAGCE SAVQQCLYAG LRLNDDEARA KVREIVEDRT ASIPDEDLHV LGYYEWLEGL
ERGIAAHHAG MLPTFKEVVE ELFVRGLVKA VFATETLALG INMPARSVVL EKLVKWNGEQ
HADITPGEYT QLTGRAGRRG IDVEGHAVVL WQRAMSPEHL AGLAGTRTYP LRSSFKPSYN
MAVNLVEQFG RHRSRELLET SFAQFQADKS VVGISRQVQK NEEGLEGYKA SMTCHLGDFE
EYARLRRQLK DRETELAKQG AAQRRVAAAA ALEKLKPGDV IHVPTGKYAG LALVLDPGLP
AGRANGHRGF DHVDGPRPLV LTAERQVKRL ASMDFPVPVE ALERMRIPKS FNARSPQSRR
DLASALRTKA GHVVPDRHRK GRAAAADDQE IARLRLELRA HPCHGCDERE DHARWAERYH
RLKRDTSQLE RRIEGRTNTI ARTFDRIVAL LTELDYLRGD EVTEHGKRLA RLYGELDLLA
SECLRAGVWE GLSPGELAAC VSALVYESRV GDDALAPKLP SGAAKAALGE MVRIWGHLDA
LEEEFKISQT EGVGQREPDL GFAWAAFMWA GGKGLDEVLR EAEMPAGDFV RWCKQVIDVL
GQIAAAAPRD GDSTVAKNAR KAVDQLLRGV VAYSSVG
//
