ID A0A3S8W7L3_9ACTN Unreviewed; 442 AA.
AC A0A3S8W7L3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Terpene synthase {ECO:0000256|RuleBase:RU366034};
DE EC=4.2.3.- {ECO:0000256|RuleBase:RU366034};
GN ORFNames=DMA15_10160 {ECO:0000313|EMBL:AZM52915.1};
OS Streptomyces sp. WAC 01529.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2203205 {ECO:0000313|EMBL:AZM52915.1, ECO:0000313|Proteomes:UP000269043};
RN [1] {ECO:0000313|EMBL:AZM52915.1, ECO:0000313|Proteomes:UP000269043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WAC 01529 {ECO:0000313|EMBL:AZM52915.1,
RC ECO:0000313|Proteomes:UP000269043};
RA Waglechner N., Wright G.D.;
RT "Evolution of GPA BGCs.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-2-methylgeranyl diphosphate + H2O = 2-methylisoborneol +
CC diphosphate; Xref=Rhea:RHEA:32571, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:61984, ChEBI:CHEBI:61987;
CC EC=4.2.3.118; Evidence={ECO:0000256|ARBA:ARBA00035573};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946,
CC ECO:0000256|RuleBase:RU366034};
CC -!- SIMILARITY: Belongs to the terpene synthase family. 2-methylisoborneol
CC synthase subfamily. {ECO:0000256|ARBA:ARBA00035653}.
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DR EMBL; CP029617; AZM52915.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S8W7L3; -.
DR OrthoDB; 4567121at2; -.
DR Proteomes; UP000269043; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR GO; GO:0042214; P:terpene metabolic process; IEA:InterPro.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR047945; MIB_synthase.
DR InterPro; IPR034686; Terpene_cyclase-like_2.
DR NCBIfam; NF041167; f2_encap_cargo2; 1.
DR PANTHER; PTHR35201; TERPENE SYNTHASE; 1.
DR PANTHER; PTHR35201:SF4; TERPENE SYNTHASE; 1.
DR Pfam; PF19086; Terpene_syn_C_2; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01020; Terpene_Cyclase_Like_2; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366034};
KW Magnesium {ECO:0000256|RuleBase:RU366034};
KW Metal-binding {ECO:0000256|RuleBase:RU366034}.
FT REGION 34..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 103..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..74
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 47969 MW; E0D1165011D2FCD8 CRC64;
MPAPELTPPR SGLPEAAPFG AHVLADAAAR AHDIKAAVGG PTRASSSPGP PPISPPAPPA
PPALDAPPSA PVADVPAPGA ALERALRGPS GLGTAGLRLF RREEPAPPSE PSAAPAQGPA
VPGLYHHPVP EPDPAKVEEV SRRIKSWALD EVTLYPDDWE EQFDGFSVGR YMVACHPDAP
SIDHLMVATR LMVAENAVDD CYCEDHGGSP IGLGGRLLLA HTALDPLYTT REYQPRWAQS
LHADAPRRAY RSAMEYFVGT ASPAQADRYR HDMARLHMGY LAEAAWAQTE YVPEVWEYLA
MRQFNNFRPC PTITDTVGGY ELPADLHARP DMQKVIALAG NATTIVNDLY SYTKELDAPG
RHLNLPTVLA DREGLSERDA YLKAVEVHND LMNEFEAEAA ALAAACPVPS VPRFLKGVAA
WVDGNHYWHR TNTYRYSLPD FW
//