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Database: UniProt
Entry: A0A3S8ZA21_9ACTO
LinkDB: A0A3S8ZA21_9ACTO
Original site: A0A3S8ZA21_9ACTO 
ID   A0A3S8ZA21_9ACTO        Unreviewed;       447 AA.
AC   A0A3S8ZA21;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN   Name=dnaB {ECO:0000313|EMBL:AZN30314.1};
GN   ORFNames=EJO69_08355 {ECO:0000313|EMBL:AZN30314.1};
OS   Flaviflexus salsibiostraticola.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Flaviflexus.
OX   NCBI_TaxID=1282737 {ECO:0000313|EMBL:AZN30314.1, ECO:0000313|Proteomes:UP000270021};
RN   [1] {ECO:0000313|EMBL:AZN30314.1, ECO:0000313|Proteomes:UP000270021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KCTC 33148 {ECO:0000313|EMBL:AZN30314.1,
RC   ECO:0000313|Proteomes:UP000270021};
RA   Bae J.-W.;
RT   "Complete genome sequence of Flaviflexus salsibiostraticola KCTC 33148.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in initiation and elongation during chromosome
CC       replication; it exhibits DNA-dependent ATPase activity.
CC       {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665,
CC         ECO:0000256|RuleBase:RU362085};
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR   EMBL; CP034438; AZN30314.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S8ZA21; -.
DR   KEGG; fsl:EJO69_08355; -.
DR   OrthoDB; 9773982at2; -.
DR   Proteomes; UP000270021; Chromosome.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00665; DnaB; 1.
DR   PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR   PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU362085};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU362085};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362085};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|RuleBase:RU362085};
KW   Reference proteome {ECO:0000313|Proteomes:UP000270021}.
FT   DOMAIN          181..447
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
SQ   SEQUENCE   447 AA;  49315 MW;  C7735F17A83445A3 CRC64;
     MSESGGFERT PPQNIEAEMS VLGGMLLSKD AVADVTEILK PDDFYRPSHS LIFEIIMQFF
     GEGQPADAVT VGSELQRRGE LERVGGLPYL HSLVASVPTA ANASYYATIV REQAQLRSLV
     EAGTRIVQLG YSTDGAEVDQ LVNMAQSEVY SLTDTAENRE YAAMEAIVND LVETLEHNES
     RGGELDGIPS GFRPVDDMLN GFRGGQMIIV AARPGAGKST FAMDVCRAAS VHNNLPSVYF
     SLEMNRTELS MRVLAAESSV FLDRMIKGNM TADDWRRVVV GLERISKAPL IVDDSPNLTM
     AEIRAKCRRL KQQHDIQLIV IDYLQLLTSG AKHVESRQQE VSDFSRSIKL LAKELNVPII
     AVAQLNRDSE KRETKKPMVS DLRESGSLEQ DADVVILLHR EDMYKSREEQ PSGLGEVIVG
     KHRAGPVGSI MLSFQGHYAR FVEAAEI
//
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