ID A0A3S8ZAF0_9ACTO Unreviewed; 762 AA.
AC A0A3S8ZAF0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=EJO69_09050 {ECO:0000313|EMBL:AZN30434.1};
OS Flaviflexus salsibiostraticola.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Flaviflexus.
OX NCBI_TaxID=1282737 {ECO:0000313|EMBL:AZN30434.1, ECO:0000313|Proteomes:UP000270021};
RN [1] {ECO:0000313|EMBL:AZN30434.1, ECO:0000313|Proteomes:UP000270021}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KCTC 33148 {ECO:0000313|EMBL:AZN30434.1,
RC ECO:0000313|Proteomes:UP000270021};
RA Bae J.-W.;
RT "Complete genome sequence of Flaviflexus salsibiostraticola KCTC 33148.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
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DR EMBL; CP034438; AZN30434.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S8ZAF0; -.
DR KEGG; fsl:EJO69_09050; -.
DR OrthoDB; 9766909at2; -.
DR Proteomes; UP000270021; Chromosome.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000270021}.
FT DOMAIN 78..265
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 373..638
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 700..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 710..755
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 81004 MW; 8A76165279813B9A CRC64;
MSSPHRPSQA APATMVSALL AFLLACTAGG LVLAGLAMPF VAATGTVSNA STSLFDDLPT
ELTFTEPSEQ SVILAADGTE LARFYAENRV VVGSEDISQH LKDAVVAIED ERFYDHNGID
PQGLIGAAFN NFSGGQLAGG STITQQYVKN LLIEEGRNSN DPELIAAATE RTIARKLSEA
RTAMAVEKQM EKDEILTGYI NIAMFGPSQY GAEAASQFFF SVPANELTIP QAAMLAGITQ
SPARWNPISN PEQAKSRRDT VLAKMYELGY ITEEQFRESV NVSIDEMLNV SPSVNGCESA
GISVYFCDYV VKDLLASDSW GESHEDRLNK LYRGGLIIHT TLDTGKQQAA YESVTTNVPV
NDPSGVEMAM SSVEPGTGKI VAMVQNTNYG SATAEDPNAT TVNLNAGMTR GGGQGFQSGS
TFKVYTLIEW IRSGRSLEER VDASRDEYAR EDWTISCAPD LADAYNPSNI EGIGSGMMTV
LESTRKSVNL SFIDMAAQLD LCNITGVAAQ MGVETGNGDP LLPRPSSVLG SNNVTPLSTA
NSMATLASGG IMCEPMAFTK IESQNGDVIA EVSPSCTRVL DEEVADTTTE ALKTVVDTGG
TGFRAVVPGH EAAGKTGTAN MDYHAWFMGY TPLEATAIWL GHMEGNVSMF YTTINGQYHI
EVYGGLYPAM VFSDYHSRIL QGTPPQTFDL QTIASRDGVT VLPQGRDNPA VRPAPAPRPA
PAPAPAPAPE PAPAPEPPPE PEPAPEPAPE PPPENPDNGD EG
//