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Database: UniProt
Entry: A0A3S9PE18_STRLT
LinkDB: A0A3S9PE18_STRLT
Original site: A0A3S9PE18_STRLT 
ID   A0A3S9PE18_STRLT        Unreviewed;      3681 AA.
AC   A0A3S9PE18;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=SDR family NAD(P)-dependent oxidoreductase {ECO:0000313|EMBL:AZQ70589.1};
GN   ORFNames=EKH77_04590 {ECO:0000313|EMBL:AZQ70589.1};
OS   Streptomyces luteoverticillatus (Streptoverticillium luteoverticillatus).
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=66425 {ECO:0000313|EMBL:AZQ70589.1, ECO:0000313|Proteomes:UP000267900};
RN   [1] {ECO:0000313|EMBL:AZQ70589.1, ECO:0000313|Proteomes:UP000267900}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CGMCC 15060 {ECO:0000313|EMBL:AZQ70589.1,
RC   ECO:0000313|Proteomes:UP000267900};
RA   Feng Z., Chen G., Zhang J., Zhu H., Yu X., Zhang W., Zhang X.;
RT   "The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP034587; AZQ70589.1; -; Genomic_DNA.
DR   OrthoDB; 9778690at2; -.
DR   Proteomes; UP000267900; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd08952; KR_1_SDR_x; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 3.30.70.3290; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR036299; Polyketide_synth_docking_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 2.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 2.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 2.
DR   SMART; SM01294; PKS_PP_betabranch; 2.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 2.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR   PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267900};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          41..468
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1407..1482
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1502..1928
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3514..3589
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          2483..2508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3469..3496
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          12..39
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        2485..2508
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3681 AA;  387227 MW;  0C974FA7D8656714 CRC64;
     MHVSSTAPAS NEEKLREYLR RAMTDLHEAR ERIRQVESSR SEPIAIVGMG CRFPGGVTSP
     EGLWDLVASG TDAISPFPVD RGWDVEALYD PVPGRPGRTY SREGGFLHDA GDFDAAFFGI
     SPREALAMDP QQRLLLETSW EALERAGIDP HTLRGSRTGV YAGVMYHDYG TSVADTAEAE
     VGGFLGTGTS GSVFTGRVSY TLGFEGPAVT VDTACSSSLV ALHLAVQALR NGECDLALAG
     GVTVMAGPGT FVEFSRQRGL AADGRCKAFS NAADGTGWSE GAGVLAVERL SDALRNGRRV
     LAVVRGSAVN QDGASNGLTA PNGPSQQRVI HEALRNAGLG TGDVDAVEAH GTGTRLGDPI
     EAQALMATYG KGRATEQPLW LGSLKSNIGH TQAAAGVGGI IKMVLAMQHG ELPRTLHAEQ
     PSTEIDWSAG TVTLLNEPVP WPRHDRPRRS AVSSFGVSGT NAHVILEQAP EPTKADEPEN
     VRALSTVPVV VSARSREALR AQARRLVDHV AAASVLDLGY STAVARSAFE HRAVVLAEDS
     AALRAGLEAI AADEPSVDVV SGALVGDGGQ TVFVFPGQGT QWVGMAVPLL DESPVFAEAM
     ARCEAALAGL VDWKLTDILD DEDALRRVDV VQPACFAIMV SLAELWKSMG LQPDAVIGHS
     QGEIAAAVVS GALSLEDGAR IVTLRAQIIG RELAGHGGMA AIAQTPTDVE QRMTPWAGRL
     HIAAVNGPNA TVIAGDPDAL AEMVTACQAE GIRARTIAVD YASHSTHVET IRAELLDALA
     NIRPQASAIP FYSTVEASSL DTTALDADYW YRNLRHTVRF HDTVELLQAD GYTLFIESSA
     HPVLTPTLPD AVVATGTLRR NEGNLRRFLT STAEAFTHGA PIQWPATFGE TGAHHTDLPT
     YPFQRRHYWL EASQAQQESL SYQVAWKHLP FTGSARLTGR WLLISPTGRE TDLGQALTTH
     GATVTHLTID PTTTDRAALA TLLTAHHDQP VTGIVSLLGL AATVALTQAL GDSGLDAPLW
     TITRGAVAVT PGEAPDPEAA QLWAFGRVAA LEHPDRWGGL IDLPHTPTPR TTDHLTQALT
     NTNTEDQIAL RPSGAYGRRL VRVPVARTAD EGRQPRGTVL LVGDTTPVAE QLVRRLLAQG
     AERVLIADPS LTDLPGTLTD LAPRAAVAAG AEVTDRASLA ALLDEHSPTT VVIAPPQAAP
     TPLATTTPAE FAAAVAAKTT TAALLDALLT PGEGTEAGSD AAHDVPEFVV FSSVSGVWGG
     ARQGAYAAGT GYLDALAERR RARGLPAVSV AWTPWSGGVT AEGTSAEAMR RYGIAPLEPQ
     AALAELERAL ARGAGSVAVV DVDWERFLTS FTSVRPTALF DELPEARRMQ AAGTTTADGP
     GVADTSPGSG TELARVLRAL PVTERDKTLM DLVASHAAVV LGEGSATAVD PDRAFKDVGF
     TSMTAVELRN RLKEATGLTL PASLVFDHPN PRALAGHLRT ELLGEDADVT EPTPAPAAFH
     SDEPIAIIGM ACRFPGGVTT PEDLWDLLST GRDAITDLPD NRGWDLAELY DPDPDAAGRS
     YVRGGGFLHD AGDFDAAFFG ISPREALAMD PQQRLVLELA WESFERAGLR PTEQRGTRTG
     VFMGTNGQHY MPLLQSGTES FDGYLGTGNS ASVMSGRISY VLGLEGPAVT VDTACSSSLV
     ALHLAAQALR RGECDLAFAG GATVMSSPDP LVEFSGQRAA SPDGRCKAFA DSADGFGPAE
     GAGMLLVERL SDALRNGRRV LAVVRGSAVN QDGASNGLTA PNGPSQQRVI HEALRNAGLG
     TGDVDAVEAH GTGTRLGDPI EAQALMATYG KGRATEQPLW LGSLKSNIGH TQAAAGVGGI
     IKMVLAMQHG ELPRTLHAEQ PSTEIDWSAG TVTLLNEPVP WPQLDRPRRS AVSSFGMGGT
     NAHVVLEQAP TSADERDDSA RELSSVPVVL SGRDSGALRE QARRLIDRVD AASVLDLGYS
     TAVTRSVFEH RAVVLAKDST TLRAGLEAIA SGTPSSDVVT GVVTGGGTPR SVFVFPGQGT
     QWAGMAADLL DESPVFAAAM ARCEALLAEH LDWNLTDLIR QTDNAPSLER EDVVQPACFA
     VMVSLAELWK SMGVEPHAVI GHSQGEIAAA VVCGALSLED GVRVVALRAR LIERELAGHS
     GMLSLTLPLA ETEQRITGWG DQLSVAVIAG PTSTVIAGPL DQIETALTAC ETEGIRARRV
     PISYASHTPH TEPIRNELIH TLHNIRPQAS TIPFYSTVEA APIDTTTLNA TYWYRNLRET
     VRFHDTVELL QADGYTLFIE ASAHPVLTPT LPDNITATGT LRRNEGDLRR FLTSTAEAFT
     HGAPIQWPAT FNATNAHHTD LPTYPFQRQR YWYEPRSRRG DVTSFGMSAV DHPLLDGGVE
     LPDGGGYLYT ARLGAETQPW LREHTLLDTP LMPGAAFVDL TLWAGGRVGC ELVEELMLAA
     PLLLPESGAV RLRLVVGAAD GDGRRSVTVH SRPETGREQW EKPEESESWT RHVQATVAPA
     DEARHASLPW EESSSAASTA FRPADFYASF AERGYTYGPL FQGVKAGHDD GTAAYSEVAL
     PEGAATAGPD RFGIHPALLD AAFQTMNLGS FFPHDGQVRM PFALRGIRLY ATGAERLRVR
     VTAAGDDAVR IEGVDEGGRP VCVIDSLAVR AVPAEQFQLP GRPARGLGDG MLHRVEWPAL
     SLPSAGSPSA PHWTLIGGDV FGLAEGLSTA GVPFTAVTTL TEAVEGVENL EDADDSPTGV
     IAVSVPRSPS TDPGAVRGAV HNALELLQEL QAADTGQRLV FVTSGAVAAG RGDRLGDPVA
     AAVWGLVRSA QSEQPDRFVL VDVEEAGSVD GAALAAGLAS GEPQMAIRAG KVRVPRLATI
     PEEDAEALLP PAGARSWQLV GGSGTISELA LVPTAADTVP LGPGQVRIAV RAAGINFRDT
     LIALGMYPGE AVMGAEGAGV VTEVGPEVSG LAVGDRVLGM WTDAFAPYAV ADHRMVAHMP
     RGWSYAEAAS VPAVFLSAYY ALKHLAGLRP GQSLLVHAAA GGVGMAAVQL ARHFGAEVYG
     TASPGKWDVL RAQGLDDRHI ANSRTLDFAE QFLEATGGRG VDVVLNSLAG PFVDASLRLL
     PRGGQFVELG KADVREAERI AAEQPGTGYR VLELMEHGPG LIGEMLAELL ELFERGVLRL
     LPVAPYDLRN AREAFRTLSQ AGHIGKLVLT MPAAFDAHGT VLITGGTGNL GGTLARHLVT
     EHGVRHLLLM SRRGAQAEGA GELAAELRGL GASVTVAACD AADRAALREL LAAVPPEHPV
     TAVLHAAGVL DDGVVTSLTP ERIDGVLRPK ADAALNLHEA SLDPDLGLDL SVFVLFSSVA
     ALLGGPGQGS YAAANGFLDA LARYRRDRAL PGLSLGWGLA GSGQLTAHLD TEELHRRMAR
     GGLLPLSGEQ SMALFDTAQR VDEAFQAPVR LNIAALAAGG NVPPVLRDLL PDAAGDPGRG
     SDGASRPASG AAPADGAEAL VERLSSLGAA EQRELLLETV RTHAAVVLGH TEPEGILGER
     AFKDLGFDSL TAVEMRNRLA AATGLHLAAT LVFDNPTPAA LAEHLRERLA PETAPAAPLL
     AELESLEAVF KGLAADDVAS LAPDGITRRE IAARLAALGS RWSALQGDGA PQEEDRSIVE
     EIDTADDDDL FAFLDEKLGG S
//
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