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Database: UniProt
Entry: A0A3S9SXI9_9FIRM
LinkDB: A0A3S9SXI9_9FIRM
Original site: A0A3S9SXI9_9FIRM 
ID   A0A3S9SXI9_9FIRM        Unreviewed;       314 AA.
AC   A0A3S9SXI9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   RecName: Full=Aspartate carbamoyltransferase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            EC=2.1.3.2 {ECO:0000256|HAMAP-Rule:MF_00001};
DE   AltName: Full=Aspartate transcarbamylase {ECO:0000256|HAMAP-Rule:MF_00001};
DE            Short=ATCase {ECO:0000256|HAMAP-Rule:MF_00001};
GN   Name=pyrB {ECO:0000256|HAMAP-Rule:MF_00001};
GN   ORFNames=BBF96_06135 {ECO:0000313|EMBL:AZR73011.1};
OS   Anoxybacter fermentans.
OC   Bacteria; Bacillota; Clostridia; Halanaerobiales; Anoxybacter.
OX   NCBI_TaxID=1323375 {ECO:0000313|EMBL:AZR73011.1, ECO:0000313|Proteomes:UP000267250};
RN   [1] {ECO:0000313|EMBL:AZR73011.1, ECO:0000313|Proteomes:UP000267250}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DY22613 {ECO:0000313|EMBL:AZR73011.1,
RC   ECO:0000313|Proteomes:UP000267250};
RA   Zeng X., Shao Z.;
RT   "Genome and transcriptome analysis of iron-reducing fermentative bacteria
RT   Anoxybacter fermentans.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-
CC         aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58228; EC=2.1.3.2;
CC         Evidence={ECO:0000256|ARBA:ARBA00001363, ECO:0000256|HAMAP-
CC         Rule:MF_00001};
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       (S)-dihydroorotate from bicarbonate: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00004852, ECO:0000256|HAMAP-Rule:MF_00001}.
CC   -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase
CC       superfamily. ATCase family. {ECO:0000256|HAMAP-Rule:MF_00001}.
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DR   EMBL; CP016379; AZR73011.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3S9SXI9; -.
DR   KEGG; aft:BBF96_06135; -.
DR   OrthoDB; 9802587at2; -.
DR   UniPathway; UPA00070; UER00116.
DR   Proteomes; UP000267250; Chromosome.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1370; Aspartate/ornithine carbamoyltransferase; 2.
DR   HAMAP; MF_00001; Asp_carb_tr; 1.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P-bd.
DR   InterPro; IPR006130; Asp/Orn_carbamoylTrfase.
DR   InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf.
DR   InterPro; IPR002082; Asp_carbamoyltransf.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd.
DR   NCBIfam; TIGR00670; asp_carb_tr; 1.
DR   PANTHER; PTHR45753:SF6; ASPARTATE CARBAMOYLTRANSFERASE; 1.
DR   PANTHER; PTHR45753; ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   SUPFAM; SSF53671; Aspartate/ornithine carbamoyltransferase; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975, ECO:0000256|HAMAP-
KW   Rule:MF_00001}; Reference proteome {ECO:0000313|Proteomes:UP000267250};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00001}.
FT   DOMAIN          7..150
FT                   /note="Aspartate/ornithine carbamoyltransferase carbamoyl-P
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02729"
FT   DOMAIN          156..303
FT                   /note="Aspartate/ornithine carbamoyltransferase Asp/Orn-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF00185"
SQ   SEQUENCE   314 AA;  34422 MW;  CD8F3627EE01B776 CRC64;
     MSRLKRKHLL GLADVSKEEI SLILDTAEAM KEVFTRKVKK VPTLTGKTVV SFFFEPSTRT
     KASFDLAGKM LSANMLSLSG SSSSVAKGES LIDTGKTLEA MGADIIVIRH SAPGAPHLLA
     RYVNASIINA GDGAHEHPTQ ALLDMFTIKE KKGRIEGLNV LIVGDILHSR VARSNIFGLK
     TMGANVRVVG PATLIPKDLK NLGVEVYYSL DEALKGADVV NILRIQRERQ KKGLFPSIRE
     YHRFYGMNER IISLLKDDVL ILHPGPMNQG VEIDPIIALD DRAVIEEQVT NGVAVRMALF
     YLLAGRGNQN EKIN
//
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