ID A0A3S9W6D2_9MICO Unreviewed; 488 AA.
AC A0A3S9W6D2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Major cardiolipin synthase ClsA {ECO:0000313|EMBL:AZS35646.1};
DE EC=2.7.8.- {ECO:0000313|EMBL:AZS35646.1};
GN Name=clsA {ECO:0000313|EMBL:AZS35646.1};
GN ORFNames=CVS47_00241 {ECO:0000313|EMBL:AZS35646.1};
OS Microbacterium lemovicicum.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Microbacterium.
OX NCBI_TaxID=1072463 {ECO:0000313|EMBL:AZS35646.1, ECO:0000313|Proteomes:UP000276888};
RN [1] {ECO:0000313|EMBL:AZS35646.1, ECO:0000313|Proteomes:UP000276888}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Viu22 {ECO:0000313|EMBL:AZS35646.1,
RC ECO:0000313|Proteomes:UP000276888};
RA ORTET P.;
RT "Microbacterium lemovicicum sp. nov., a bacterium isolated from a natural
RT uranium-rich soil.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP031423; AZS35646.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3S9W6D2; -.
DR KEGG; mlv:CVS47_00241; -.
DR Proteomes; UP000276888; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09158; PLDc_EcCLS_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000276888};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AZS35646.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 220..247
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 401..428
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 488 AA; 55832 MW; F6E9F62EB8781948 CRC64;
MVDITFDASW WLILVFVSDV IIRIAAIIVV PRNRRPTAAM AWLLAIYFIP FVGVLLFLLI
GNPRLPRKRR RKQEQINEYI TETSSHLDFG TLRPHAPDWF TSLVTMNRRL GAMPLAGDNA
AHLIADYQES LDTMAAAIRT AEGYVHVEFY ILQSDDSTDN FFSALEEVAA RGVTVRVLLD
HWANRGKPFY KKTLARLDAM GAQWRLMLPV QPLKGKYQRP DLRNHRKLLV VDGTVAFMGS
QNVTDSTYNL RKNIRRGLHW VDLMVRLEGP VVASVNAVFL SDWYSETDEV LTDEIDLFDV
KSGPGDLDCQ VVPSGPGFEV QNNLRLFAAL LYSAQRRITV VSPYFVPDEA MLLAITTACQ
RGLQVELFVS EEGDQAMVYH AQRSYYESLL RAGVKIWMYR KPYILHTKCF TIDDEVAVIG
SSNMDMRSFG LNMEISLLVR GEEFVQEMRN VEDRYRRISR ELTLEEWQKQ PLRSTILDNI
ARLTSALQ
//
