ID   A0A3T1ASP3_9ACTN        Unreviewed;       549 AA.
AC   A0A3T1ASP3;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Na+/H+ antiporter {ECO:0000313|EMBL:BBH65868.1};
GN   ORFNames=ACTI_25530 {ECO:0000313|EMBL:BBH65868.1};
OS   Actinoplanes sp. OR16.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=946334 {ECO:0000313|EMBL:BBH65868.1, ECO:0000313|Proteomes:UP000282692};
RN   [1] {ECO:0000313|EMBL:BBH65868.1, ECO:0000313|Proteomes:UP000282692}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=OR16 {ECO:0000313|EMBL:BBH65868.1,
RC   ECO:0000313|Proteomes:UP000282692};
RA   Kasai D.;
RT   "Complete genome sequence of natural rubber degrading Actinoplanes sp.
RT   strain OR16 isolated form botanical garden in Japan.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for
CC       external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU366002};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU366002}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; AP019371; BBH65868.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3T1ASP3; -.
DR   OrthoDB; 57886at2; -.
DR   Proteomes; UP000282692; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   NCBIfam; TIGR00831; a_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU366002};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU366002};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        28..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        57..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        85..109
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        213..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        235..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        276..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        306..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        361..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   TRANSMEM        390..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU366002"
FT   DOMAIN          11..415
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   549 AA;  59605 MW;  ABFCC600F60EC1C1 CRC64;
     MNLEEILLFA LGAVAVIVTV RWVTEKTGLP AAVLLTLIGI AYAYLPGPNL ELEPELVLTF
     ILPPLLYNAA LDSSLLDIRR NMRTVISLSV VLVLVTALLI GLGFSLWVAG ATLAAGVALG
     AAVAPPDPVA SLAVGRRAGL PNKMVTLISG EGLLNDATAL TILTVAVTAQ ARGDFNFDNA
     VGQFVIAAAG GVMVGVAVAY AVRFLKAFRA DPLNANALSL ITPLAAYLIC ENAFVHHYVT
     ISGVLAVVVA GLIVGHDTPR YTTGASRLQT SAVWRLIDFL LEGMVFLLIG QQVPDVVDGL
     SKYATSTIVI ALAVTLGVVL LLRPLWLVLT QWLPRSLHTR LGGQNDDETE AREVPLTGKE
     ITVLSWAGTR GVITLAAIFT LPVGFPDREL LHFCAIAVVL VTLVGQGLTF APLVRHLGLR
     ANQTDRARER NEARSAAVRA GLERLDDIQE QQHDNVEDEA IETMRKQLQI RLDRYRRRLD
     LLEQVDSNEV PISPQYEAAL VVRQAVIDAE REELLRRRDA GHLNDDSLRV LNRELDHEEL
     ILPKRHKDH
//