ID A0A3T1B5K1_9ACTN Unreviewed; 1091 AA.
AC A0A3T1B5K1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=ACTI_70560 {ECO:0000313|EMBL:BBH70371.1};
OS Actinoplanes sp. OR16.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=946334 {ECO:0000313|EMBL:BBH70371.1, ECO:0000313|Proteomes:UP000282692};
RN [1] {ECO:0000313|EMBL:BBH70371.1, ECO:0000313|Proteomes:UP000282692}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OR16 {ECO:0000313|EMBL:BBH70371.1,
RC ECO:0000313|Proteomes:UP000282692};
RA Kasai D.;
RT "Complete genome sequence of natural rubber degrading Actinoplanes sp.
RT strain OR16 isolated form botanical garden in Japan.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AP019371; BBH70371.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3T1B5K1; -.
DR Proteomes; UP000282692; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 3.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 2.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 4.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 2.
DR Pfam; PF08448; PAS_4; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 4.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 2.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 4.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 179..236
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 553..603
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 600..644
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 672..724
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 725..795
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 798..850
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 882..1089
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 839..872
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1091 AA; 118132 MW; AF40B71E0F2FED05 CRC64;
MSGVSVQPSP VQGAVSDPAR LAAVKATGLL DHDSPILDRI TALAERLVGG RATLVTLVQE
ERQCFVSQSG PAASPAFRET PLTHSYCQYV VESGRPMVVP DAREHPLLRG NPAIVEFNAI
AYLGVPLRSP DGYVLGTLCA VDREPREWTG TDVAVMEDLA AAATAEIAAQ VAVQEAAEAS
ARLEKIVGST LDAYVATDAA GRITGWNEAA EKMFGWGVPE ALGRTMSELI IAPQDRREHA
AWLMAMSFEV DVDPAGRRVD LTGLQRGGRQ FPIELSLTAL DRPGGMAAYM FVRDLTAQRR
SEMLRNLEYS VAGTLAASES VEQATDLVVE AVAEGLGWPY IEYWHLDDDE SLMVRLAVAA
RERAVTAPME SFTEFSRGDG VVGQVWQSAS SRWIRELPVA DMPRSAAAEA SRLNTAVAVP
VRNGTHVVGV LAAFERRRTE PDPELMAALE TVAAHIGQYV HRRRAEELEL ELSRARRDFD
RVIANLEDFI WTVRVDAPGE VEMVYSSHDR TGIFGGLVPS NAELSDVASS MVHPEDLPQF
AAFGAEMAGG QSAQMTCRVI GADGVTRWVW TRAVPRQEGD VCFIDGVCSD VTERQHDQER
LRQQAELLDL APTAVIVKDL DDRVTYWNRG AEVTYGWDAD AALGCPTHRL LDTRFPVLRT
LVDTELAENG EWHGELDHLR SDGTRITVLS HMAVQHDDGG HPVAILEVNI DVTARKLAER
RVADSEKRLR TQFSLATVGQ ATIALDGRFQ QVNPALAAML GRTVATVEGM TLDDITHPDE
RADNHRAAAR LFTQDLPLDR HLRMLHADGH LVDAAMGMSL VRDTDGQPVS FIAVLQDVTA
RLAAERERAA AEAELAERND ELEDSNSQLA AANTLKLDLM GMLSHEIGTP LNTISGYAEL
LLGSLDDVKP PHRKAIEVIA RSARRLEILR GEILTMCTLD AGQMSATPEP VDLGPALGDI
LAGLEVSPPV SCPPGTTVLV HPSHLQQIVT NFCTNAAKYG GGVTEVTVER RGGTAVIGVH
DEGEGIPEEL RPQLFERFTR AAGMSPTIKG HGLGLYIVKG LAEANDGTAG YEPNPKGGSV
FTLTLPVARL T
//
