ID A0A3T1CXU3_9BACL Unreviewed; 1173 AA.
AC A0A3T1CXU3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Transcription-repair-coupling factor {ECO:0000256|HAMAP-Rule:MF_00969};
DE Short=TRCF {ECO:0000256|HAMAP-Rule:MF_00969};
DE EC=3.6.4.- {ECO:0000256|HAMAP-Rule:MF_00969};
GN Name=mfd {ECO:0000256|HAMAP-Rule:MF_00969,
GN ECO:0000313|EMBL:BBI30653.1};
GN ORFNames=KCTCHS21_00520 {ECO:0000313|EMBL:BBI30653.1};
OS Cohnella abietis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX NCBI_TaxID=2507935 {ECO:0000313|EMBL:BBI30653.1, ECO:0000313|Proteomes:UP000289856};
RN [1] {ECO:0000313|EMBL:BBI30653.1, ECO:0000313|Proteomes:UP000289856}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HS21 {ECO:0000313|EMBL:BBI30653.1,
RC ECO:0000313|Proteomes:UP000289856};
RA Jiang L., Kang S.W., Kim S., Jung J., Kim C.Y., Kim D.H., Kim S.W., Lee J.;
RT "Complete genome sequence of Cohnella hallensis HS21 isolated from Korean
RT fir (Abies koreana) rhizospheric soil.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC release of RNAP and its truncated transcript from the DNA, and
CC recruitment of nucleotide excision repair machinery to the damaged
CC site. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC RecG subfamily. {ECO:0000256|HAMAP-Rule:MF_00969}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC {ECO:0000256|HAMAP-Rule:MF_00969}.
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DR EMBL; AP019400; BBI30653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3T1CXU3; -.
DR KEGG; cohn:KCTCHS21_00520; -.
DR OrthoDB; 9804325at2; -.
DR Proteomes; UP000289856; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR GO; GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition; IEA:UniProtKB-UniRule.
DR CDD; cd17991; DEXHc_TRCF; 1.
DR Gene3D; 2.40.10.170; -; 1.
DR Gene3D; 3.40.50.11180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2060.10; Penicillin-binding protein 1b domain; 1.
DR Gene3D; 3.90.1150.50; Transcription-repair-coupling factor, D7 domain; 1.
DR HAMAP; MF_00969; TRCF; 1.
DR InterPro; IPR003711; CarD-like/TRCF_RID.
DR InterPro; IPR036101; CarD-like/TRCF_RID_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR004576; Mfd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR037235; TRCF-like_C_D7.
DR InterPro; IPR005118; TRCF_C.
DR InterPro; IPR041471; UvrB_inter.
DR NCBIfam; TIGR00580; mfd; 1.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF02559; CarD_TRCF_RID; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF03461; TRCF; 1.
DR Pfam; PF17757; UvrB_inter; 1.
DR SMART; SM01058; CarD_TRCF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00982; TRCF; 1.
DR SUPFAM; SSF141259; CarD-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF143517; TRCF domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00969};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00969};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00969};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00969}; Reference proteome {ECO:0000313|Proteomes:UP000289856}.
FT DOMAIN 626..787
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 808..962
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1173 AA; 133327 MW; 3663C1C0FC1DB243 CRC64;
MKPLIQSLVT DPDLISIIQG LKGGMREQLV AGLSGSARQV TLAGMYRELQ RPILVITHNM
FSAQKMTDDL QECLSTDEVL LYPANELIAA ETAISSPETS ARRLEVLLKL AEGFRGIIVV
PFAGVRKFQP DLLTMSEAHI DLKVGDTLPM EQFLRGMIEL GYERVDRVEQ KSHLSVRGGI
VDFFPLASSS AYRVEWFDDE IDSIRTFDPA DQRSIDKLES YTVQPCREWI AGERRFQNAA
KHAQDLLEKQ LEKMADRQAK ERLSSEISRE IELLRQNVYF TEIYKYISLL YPERQTLLDY
IPKDTVLLMD EPNRLGETAR QLERDESEWT THLLQQGKSL PGFVLAVPAE QALYPKGFQT
VYMSLFVRQI PHTQPQNIIN FVCRSMQNFH GQMNVLKAEM ERWRKGGIKI VMLAGNSERA
DRMRRVLEDY QIEAPEILQG NLQSGFELPS IKLVVITEGE MFTQKQRKAR RVDRHLDNAE
RIKSYTELKV GDYVVHQNHG VGKYLGIGTL EVGGIHKDYL HIVYAAGDRL SVPVEQFDLI
QKYVGNEDKE PKVSKLGGSD WNRAKSKVRS SVQDIADDLI KLYAARQSTV GFGFGEDTPY
QQEFEEMFPY EETVDQLRAI REIKEDMQTA RPMDRLLCGD VGYGKTEVAI RAAFKAAIEG
KQVAVLVPTT ILAQQHYETF RERFSGYPFN IKVLSRFRTR KEQTDTMKGL KAGTVDVVIG
THRLLSQDII FKELGLLIVD EEQRFGVTHK EKLKRIKTNV DVLTLTATPI PRTLHMSMLG
VRDLSVIETP PENRFPVQTY VVEYSPTLIR EAVERELARD GQVYYLFNRV QGIYQMAEQI
SALVPDARVA VAHGQMSEQE LERTILDFLD GEYDVLVSTS IIETGVDIPN VNTLLVHDAD
RMGLSQLYQL RGRVGRSNRI AYAYFTYQRD KVLTEVAEKR LQSIKEFTEL GSGFKIAMRD
LTIRGAGNLL GAEQHGFIAS VGFDLYSQML AEEIQSRKSE MGGVVLPPQP VNTQLDLGVD
AYLPPEYIYD SIQKIEIYKK VAAATSLEDV ADLFEELMDR FGEPPKAVLN LMTVVRLKVY
GRQYGIESIV RRGDEVTLKL EERRREDVDS SKLKALEAKF QGRMVQAITA QQLLIRLKVR
GLDENALLAL VEDFLVQYKE ATKSKGELQD VAP
//
