ID A0A401GEJ9_9APHY Unreviewed; 918 AA.
AC A0A401GEJ9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=SCP_0303150 {ECO:0000313|EMBL:GBE80600.1};
OS Sparassis crispa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Sparassidaceae; Sparassis.
OX NCBI_TaxID=139825 {ECO:0000313|EMBL:GBE80600.1, ECO:0000313|Proteomes:UP000287166};
RN [1] {ECO:0000313|EMBL:GBE80600.1, ECO:0000313|Proteomes:UP000287166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30375506; DOI=10.1038/s41598-018-34415-6;
RA Kiyama R., Furutani Y., Kawaguchi K., Nakanishi T.;
RT "Genome sequence of the cauliflower mushroom Sparassis crispa
RT (Hanabiratake) and its association with beneficial usage.";
RL Sci. Rep. 8:16053-16053(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBE80600.1}.
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DR EMBL; BFAD01000003; GBE80600.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401GEJ9; -.
DR STRING; 139825.A0A401GEJ9; -.
DR InParanoid; A0A401GEJ9; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000287166; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF6; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000287166};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 177..197
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 416..439
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 489..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 589..610
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 617..638
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 858..917
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 100445 MW; 8EA7B176CECA72EE CRC64;
MADDGLPSGP YSGPSRTTWR RQRLLRIGSE TSTTDGDRAP LCSPTAATVR PSYGTAPPQR
RSSVDSGRPR RTRSVLSILG LVKSSVPSSP VSHPPSIRES YLASQRPISA YDAPVVQSPV
LEEPEPDVTI NGVRVWYASF TSIDWLHDAI KDSARRARLR RPRSRSARLR RQLDRTVGWL
IVTIVGFFTA VAAFLIIRTE QWLFDLKDGY CRDAWWKARR FCCPAPEDVF ATRPAFLTLA
EDESCPAWRT WPQVFEPMAV ENGSWLQVEM MDYLAYTVVA LSLAVISCLL TIHLTASTSF
VTRKDSAVVP PEYAHGEGDQ KVLDNPNGAE QKRKVMYYAA GSGIPEIKTI LSGFVIHGYL
GARTLFTKSI GLALSVGSGL TLGKEGPFVH IASCVGNIVS RFFSKYETNE AKRREILSAA
SAAGVAVAFG APIGGVLFSL EEVSYFFPPK VMWRSFFCAM VAAMTLRFLD PFGSGKLVLL
QVTYDKDWHA YELIFFLLLG VFGGVWGAYF SKMNFLWTRH VRNGTWLRRH PVLEVVLVTL
ATSVLCFVNP YTRWGNTELV YKLFCECAPG AADTHGLCVL DPPQHALPVI RAILVAMLIK
GALTVVTFGI KLPAGIFIPS LAVGACAGRI VGILVQWLQF TYPDSPVFAA CKGDLDCVIP
GLYAMVGAAA SLSGVTRTTV SLAVIMFELT DTLTYAVPVM LAVLVAKTVA DAIAPKGIYD
LCIELAQLPY LDAKHDYGWG SVQIIDVTDR DVDVIRVDVP NTVKSLRDRL QRLLTAGKAD
GGFPILRAHE DGHRMVGYIG ASELEHGLCI IADEPEKSVS FHPAAPYAHG SALGSSYSSL
EAGAHVVGAD PFDFSCYMDQ APLTVQSNSP LELVQQFFTK LGARYVVVMD TDGYYEGVID
KKAWLAFLGE LEEKAASK
//
