ID A0A401GS22_9APHY Unreviewed; 721 AA.
AC A0A401GS22;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 10.
DE SubName: Full=Ras GEF {ECO:0000313|EMBL:GBE85032.1};
GN ORFNames=SCP_0702180 {ECO:0000313|EMBL:GBE85032.1};
OS Sparassis crispa.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Sparassidaceae; Sparassis.
OX NCBI_TaxID=139825 {ECO:0000313|EMBL:GBE85032.1, ECO:0000313|Proteomes:UP000287166};
RN [1] {ECO:0000313|EMBL:GBE85032.1, ECO:0000313|Proteomes:UP000287166}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30375506; DOI=10.1038/s41598-018-34415-6;
RA Kiyama R., Furutani Y., Kawaguchi K., Nakanishi T.;
RT "Genome sequence of the cauliflower mushroom Sparassis crispa
RT (Hanabiratake) and its association with beneficial usage.";
RL Sci. Rep. 8:16053-16053(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBE85032.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BFAD01000007; GBE85032.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401GS22; -.
DR STRING; 139825.A0A401GS22; -.
DR InParanoid; A0A401GS22; -.
DR OrthoDB; 1584469at2759; -.
DR Proteomes; UP000287166; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000287166}.
FT DOMAIN 278..410
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 473..714
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 721 AA; 81145 MW; 1260D37454A0F661 CRC64;
MASVEKSTIS GPRPLRSRTL PLRLCGQATW DVNSNLTAVT HGFSRVRCSL VYRNFDNLSE
AAASLSKAIT RTLDFSGHGR SSVAATSGFH SAHNGLVFAC ELLQSHLSTL HQDLDGEALD
IALSRASQLL DATMLNYRGF LRAVEMNNLQ VFSSNDVQAI VHRESVEQNA AASVPKSRRK
SVLSRLRTFS LSCMLSELVS PLDVLNGRST ASAITLVEPS PMSIKSRQTS FRAKCGDTKN
ASYNSDITLD LEYIRQMLLS NASSDLHPEE TMDVVRNADG SISLATFSEL IHMATDQREF
LKGYLADLVD VLFLYFRSFA TPEKFFEMLL ERYHGKAASA LGQEDLPRWN QDHNFSKVQV
TSLIYMWLKF YWKPTTDECV RQRIIEFSHD SIASDTDIPL QLVKLVTSTI CECSPGRTGH
EGGRWLEKEI TRTETAAGTF PPTDFQARLQ YLETFGTDDT SLVNARYFLG TGGAEEIARH
LTILESELFH TFVPEDLINF ADRGLQSKLV AWRKFSDALS LWVRDCILEH SGAADRARLL
EMFVTIAQDC KTMRNFSSAQ IIVVALRSSC ISRLQQTAKA VSQRCRDVYQ ELEEFFDSSK
NWSPCRTELV QNLPAVPLAM IFVKDIIHCR DGLPRIMSTV GTSSKPSQEY IPLNYYRQMT
KIVRGLEKCY GSYKLQRSEF LYGWLKHNIA RLQQDSYSTH EGRLVQKSLL LEPKSLTPSL
I
//
