ID A0A401INM4_APHSA Unreviewed; 884 AA.
AC A0A401INM4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AsFPU1_4304 {ECO:0000313|EMBL:GBF82870.1};
OS Aphanothece sacrum FPU1.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Aphanothecaceae; Aphanothece.
OX NCBI_TaxID=1920663 {ECO:0000313|EMBL:GBF82870.1, ECO:0000313|Proteomes:UP000287247};
RN [1] {ECO:0000313|Proteomes:UP000287247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FPU1 {ECO:0000313|Proteomes:UP000287247};
RA Kanesaki Y., Yoshikawa S., Ohki K.;
RT "Physiological properties and genetic analysis related to exopolysaccharide
RT production of fresh-water unicellular cyanobacterium Aphanothece sacrum,
RT Suizenji Nori, that has been cultured as a food source in Japan.";
RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBF82870.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BDQK01000017; GBF82870.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401INM4; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000287247; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000287247}.
FT DOMAIN 737..753
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 663..670
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 884 AA; 98554 MW; CAB363CB71BDF351 CRC64;
MTNYSESNPT SNIATSKSPH TDYRHLDFDK LTPMNQHYVT VKKQYPNALL MYRVGDFFEC
FFQDAVTISQ ELEIALTSKE GGKEIGRVAM TGVPHHALDR YSRLLVEKGY ALAICDQVED
SAQAAAEGRM VERKITKLLT PGTLTDEGML TAKRNNFLAA IVIAGEHWGL AYADISTGEF
FTTQSQELSN LNLELLRLQP SEILIPTNAP DINSLLRPGE KSDYLNNNLP DCFCYSLRSQ
TSFTLNEAKP RLLITFGVRS LEGMGCEHLP LAIRAAGGLL EYLEDTQKAH QVPLQALRTY
NQVDFLILDH QTRRNLEITQ TIRDGSFHGS LLWALDRTCT PMGGRALRRW LLEPLLSIKG
IIARQDTIQE LNDNPSLRQD LRQLLRHIYD LERITGRVGA GTANARDLLS LAESLVKLTE
LSQLARLGTS PYLKALQTIP PELEQLGKHV VNHLVETPPL HLKDGGVIRD GINSDLDMMR
HRLKDDHQWL ANLEITERQR TGVSNLKVGY NKTFGYYISL PRSKAEQAPD NYVRKQTLTN
EERYITSELK ERENRILTAE DDLNKLEYEI FVELRLEVAQ KGQQIRHIAK AVAAIDVLGG
LAEVAVFQGY CRPQIMEGRQ IEIIEGRHPV VEQSLAVGLF VPNSTRLGNS KTEDTPDLII
LTGPNASGKS CYLRQVGLIQ LMAQTGSFIP ATSAKLGISD RIFTRVGAVD DLATGQSTFM
VEMNETANIL NHGTNKSLIL LDEIGRGTAT FDGLSIAWAV AEYLATEIQG RTIFATHYHE
LNELASILSN VANYQVTVQE LAHEIIFLHQ VRPGGADKSY GIEAGRLAGL PPSVITRAKQ
VMNQIEKHSK IALGLRKGIK KVNPVKDTKT KGELIEQLDI FGDN
//
