ID A0A401IR62_9LACO Unreviewed; 601 AA.
AC A0A401IR62;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=LFYK43_04890 {ECO:0000313|EMBL:GBG94030.1};
OS Ligilactobacillus salitolerans.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1808352 {ECO:0000313|EMBL:GBG94030.1, ECO:0000313|Proteomes:UP000286848};
RN [1] {ECO:0000313|Proteomes:UP000286848}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YK43 {ECO:0000313|Proteomes:UP000286848};
RA Tohno M., Tanizawa Y.;
RT "Draft genome sequences of Lactobacillus sp. YK43.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GBG94030.1}.
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DR EMBL; BFFP01000005; GBG94030.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401IR62; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000286848; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.220.20; DNA methylase specificity domains; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR044946; Restrct_endonuc_typeI_TRD_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:GBG94030.1};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 107..386
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 552..586
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 601 AA; 67525 MW; 25CFF79C0415CDBF CRC64;
MNEKINNKLW SIANKLRGSG VSPEQFLHVI CMVLYVGHED KEVLRKLMLA DKEELLTAIA
KVQVDQPTKI IGLADEDLLA AIPTNVLVEV YDLVKYLDPQ EDAEFLEELM SQMQQNAGKR
GSILDDFPQT GKLMMELAAP TPQEKIYDPY FRTGIRYSEL LAANPDQQIY AQEPNQLAYV
AGQVRSYLRQ AGNVQVLHQD VLQEKLSPKI NGVVDLTLAS PPMHRRMRPE DLDKERYRFG
KPSSIVDWAY VMSGLDVLND TGRAIFNLSN SAVFRGNIDA EIREKIVSAD LIEAVIALPD
ERKVASGVPR VLVLFRMHKT SHQGQVLMIN ARHLSKKKFD FSQAVHQQIK QILEQGQEKE
GVSAWVNNET ITKNNGILVP DQYIEQDVFK LSPDLKIRLN REKIGQVPML ELGQVAELYR
GFNVTSSDEE PDGSYGLIKI SDLAGGKINY AQLARTNGKA NTRVENYQVQ KGDVLLPIRG
ELRAAVVVTE AHPNVLLTQN IIGVRPIEGK LDSQWLVEYL NSPVGRALLS GISVGTMIKQ
IPLQQLKKLA ILPNQTQAVA DYREKKDGLE EQLRQIQLQM EQAKNEFYQA SGIGELFEKS
N
//
