ID   A0A401JCR9_9PROT        Unreviewed;       425 AA.
AC   A0A401JCR9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Phosphate regulon sensor protein PhoR {ECO:0000256|ARBA:ARBA00019665};
DE            EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN   ORFNames=SFMTTN_1163 {ECO:0000313|EMBL:GBL45356.1};
OS   Sulfuriferula multivorans.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Sulfuricellaceae; Sulfuriferula.
OX   NCBI_TaxID=1559896 {ECO:0000313|EMBL:GBL45356.1, ECO:0000313|Proteomes:UP000286806};
RN   [1] {ECO:0000313|Proteomes:UP000286806}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TTN {ECO:0000313|Proteomes:UP000286806};
RA   Watanabe T., Kojima H., Fukui M.;
RT   "Whole-genome sequencing of sulfur-oxidizing chemolithoautotrophs
RT   representing nine proteobacterial species.";
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Member of the two-component regulatory system PhoR/PhoB
CC       involved in the phosphate regulon genes expression. PhoR may function
CC       as a membrane-associated protein kinase that phosphorylates PhoB in
CC       response to environmental signals. {ECO:0000256|ARBA:ARBA00025207}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GBL45356.1}.
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DR   EMBL; BGOW01000010; GBL45356.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401JCR9; -.
DR   Proteomes; UP000286806; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:InterPro.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 1.10.287.130; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR021766; PhoR.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   InterPro; IPR014310; Sig_transdc_His_kinase_PhoR.
DR   NCBIfam; TIGR02966; phoR_proteo; 1.
DR   PANTHER; PTHR45453; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR   PANTHER; PTHR45453:SF1; PHOSPHATE REGULON SENSOR PROTEIN PHOR; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF13188; PAS_8; 1.
DR   Pfam; PF11808; PhoR; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphate transport {ECO:0000256|ARBA:ARBA00022592};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022592}.
FT   TRANSMEM        6..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          202..418
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50109"
SQ   SEQUENCE   425 AA;  47734 MW;  1423A7449E380D80 CRC64;
     MLGGILFAAL LAALLFNVST GIALLVLGVL GYLVYNLRQM AALIRWLERG ERGGIPRAYG
     AWDDIFYGLE RLLRRQKRST TKLSALLDRF EHAAQAIPDG IVMLNDTDQI DWFNPAASKH
     FSLDNAADRG QFIGYLIRQA PFHEYLAGHD YSEPLIMKSP ASRDVTLSVQ LVPFGDKRKM
     LISRDITQIE LVDSMRRDFV ANVSHELRTP LTVVGGFLET FADMEHINPV DFRRYSDLMQ
     QQTERMRMLV EDLLTLSRLE SPQNRLQETP INVPALAQSL FQDAQSLSGE RHHIELFIDI
     DRWVMGNPDE LRSAFGNLVS NAVRYTPKDG NITLRWAARG GEVCFSVTDT GDGIEPHHIP
     RLTERFYRVD RGRSRETGGT GLGLAIVKHV LTRHQARLMI DSQVGKGSCF AACFPSSRVM
     APPAA
//