ID   A0A401KIH5_ASPAW        Unreviewed;       413 AA.
AC   A0A401KIH5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Demethylsterigmatocystin 6-O-methyltransferase {ECO:0000313|EMBL:GCB19113.1};
GN   ORFNames=AAWM_01998 {ECO:0000313|EMBL:GCB19113.1};
OS   Aspergillus awamori (Black koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=105351 {ECO:0000313|EMBL:GCB19113.1, ECO:0000313|Proteomes:UP000286921};
RN   [1] {ECO:0000313|EMBL:GCB19113.1, ECO:0000313|Proteomes:UP000286921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 58123 {ECO:0000313|EMBL:GCB19113.1,
RC   ECO:0000313|Proteomes:UP000286921};
RA   Kusuya Y., Shimizu M., Takahashi H., Yaguchi T.;
RT   "Aspergillus awamori IFM 58123T.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB19113.1}.
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DR   EMBL; BDHI01000002; GCB19113.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401KIH5; -.
DR   Proteomes; UP000286921; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF1; HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:GCB19113.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286921};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:GCB19113.1}.
FT   DOMAIN          235..377
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   413 AA;  45956 MW;  F2CBE3284780E271 CRC64;
     MFTNSSHANG ASQKPVDGLI RQVAQAADSF HNSHDEADRL AALQAAQKLV EAFQKPQDAV
     YNLAYSPTHV MCVRIAMDLG IFSTLSERNG PVTLEDLAAT KGADLVLTGN VVLIPSMNKL
     LSYFGNRKSA AYPCRDWTGL VGPCFDIGMP TLAKVPEFLR MTNFQNPSGA VKGALQYAEK
     TEMSLWDWVP TKPGFLDACN TFMEADRGSR PSWLEWFPVK ERIIDGFHQG ESNVLLVDVA
     GGRGHDLVAF ESKFSEVQGR LILEDLPHVV AEATQHPKIE HVSFDLFQAQ PIQGARTYYM
     KFILHDWSDE ESRQILSHLA AAMKTGYSKL IIEEFVLADK DCAMLPAMWD WEMLIFCNSM
     ERTASQWTKV LDSAGFRVVK FWAPPGDGQS IIEAELKEPA EPESSRLARS SHI
//