ID   A0A401KII9_ASPAW        Unreviewed;       890 AA.
AC   A0A401KII9;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Cullin-4A {ECO:0000313|EMBL:GCB19061.1};
GN   ORFNames=AAWM_01946 {ECO:0000313|EMBL:GCB19061.1};
OS   Aspergillus awamori (Black koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=105351 {ECO:0000313|EMBL:GCB19061.1, ECO:0000313|Proteomes:UP000286921};
RN   [1] {ECO:0000313|EMBL:GCB19061.1, ECO:0000313|Proteomes:UP000286921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 58123 {ECO:0000313|EMBL:GCB19061.1,
RC   ECO:0000313|Proteomes:UP000286921};
RA   Kusuya Y., Shimizu M., Takahashi H., Yaguchi T.;
RT   "Aspergillus awamori IFM 58123T.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB19061.1}.
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DR   EMBL; BDHI01000002; GCB19061.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401KII9; -.
DR   STRING; 105351.A0A401KII9; -.
DR   Proteomes; UP000286921; Unassembled WGS sequence.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF126; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000286921};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          520..763
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          1..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..137
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   890 AA;  101055 MW;  ED2C19834D219A4A CRC64;
     MQQNSRGTTE QRSGKRKSIG KRKLSDQGEA LQQPQQQQAN ISEFLSRNHT TPARGHHQQT
     SPTSKRLRLS PPSSDSVPSA YSRDRSASDR MYNFANAESR PGAPMGQSAS GADLPNTTTK
     PRTFNATSRQ NNFTPHTGAK RLVVKNLRTG SRLNQESYFE KIWGQLDAAL SAIFGGGKPE
     ISLEELYKGA ENVCRQGRAA VLAKRLQDRC REHVSGRLRD KLVAKAADGS NVDTLRAVVE
     AWSQWQSKLV TVRWIFYYLD QSFLLHSKEF PMIREMGLIQ FRQHIFSDAV LQPKILQGAC
     DLVEADRGEE QSVVADSLLL RNTIELFHGL DIYTTGFEPL LISESKKYFS SWAQREATGY
     LATFAENSHR LIEREVTRCE LFSLNRSTKQ MLSELLDRAL VTEQENVLLN QPDILGLLRA
     GNKVALERLY SLLQRKDLGA KLKAAFSGYI IEEGSGIVFD EDKEADMVAH LLEFKQQLDD
     IWVNSFHRNE ELGHTLREAF ETFINKGRKS ESTGGTDNPK TGEMIAKYVD RLLKGGWKLA
     PARKAEDMPL ADEDAEIDRQ LDQVLDLFRF VHGKAVFEAF YKNDLARRLL MGRSASDDAE
     KSMLARLKTE CGSSFTHNLE SMFKDMDVAR DEMSAYSSIQ RERRDRLPVD LNVSVLSASA
     WPTYPDVQVR IPPEIATAVD DFEKFYNTKY NGRKLNWKHQ LAHCQLRARF PKGDKELVVS
     SFQAIVLLLF NDIPEGGSLG YAQIQEATML SDQELKRTLQ SLACAKYRVL SKKPKGRDVN
     TTDEFSYNAA FTDPKMRIKI NQIQLKETKE ENKTTHERVA ADRHYETQAA IVRIMKSRKT
     ITHAELVAEV IKATRSRGVL EPADIKKNIE KLIEKDYMER EEGNRYQYVA
//