ID   A0A401KM67_ASPAW        Unreviewed;      1050 AA.
AC   A0A401KM67;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Endoplasmic reticulum membrane protein 65 {ECO:0000313|EMBL:GCB20360.1};
GN   ORFNames=AAWM_03245 {ECO:0000313|EMBL:GCB20360.1};
OS   Aspergillus awamori (Black koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=105351 {ECO:0000313|EMBL:GCB20360.1, ECO:0000313|Proteomes:UP000286921};
RN   [1] {ECO:0000313|EMBL:GCB20360.1, ECO:0000313|Proteomes:UP000286921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 58123 {ECO:0000313|EMBL:GCB20360.1,
RC   ECO:0000313|Proteomes:UP000286921};
RA   Kusuya Y., Shimizu M., Takahashi H., Yaguchi T.;
RT   "Aspergillus awamori IFM 58123T.";
RL   Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the TAPT1 family.
CC       {ECO:0000256|ARBA:ARBA00008803}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB20360.1}.
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DR   EMBL; BDHI01000007; GCB20360.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401KM67; -.
DR   STRING; 105351.A0A401KM67; -.
DR   Proteomes; UP000286921; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008010; Tatp1.
DR   PANTHER; PTHR13317:SF4; TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG; 1.
DR   PANTHER; PTHR13317; UNCHARACTERIZED; 1.
DR   Pfam; PF05346; DUF747; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286921};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        918..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..139
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          252..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          481..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..108
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..509
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        510..524
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1050 AA;  116833 MW;  7FADF6E3635FF9C0 CRC64;
     MDELPGHLNQ RASDTIAHVA APGGQEAPVS PRKREHESGM DHESHSLGIE KLQQSRPMES
     RPADNEDRAN GILSRNMQRG GSATSDTMNT GERSNREEAV HRFGALVSDH ELNRFPSQPT
     VNGDQKSGQP ALPSDQALGM VFEHSLEGAD SADHRTTPRT SLVDVFEGPD VASVFHQWSR
     NTSPVRNQDK EQERVVKLSP ARMQELASSP QSIPYRAAPP ESDRGRRAVS DGMHAAISPS
     QPDQSATLLP SEQKVTGDSV PKLRPNKDLA IDVSAATAAK QPVRSRPQGS RAVSTPNSRR
     QTMPTTSERL TQTWTSRGKQ ERASLSRESD GKHLTPSPHI TGTEPALPSP MPPTIPLPPL
     SVPTYLQLEL ASGRPSPLYI HRSAMSDFPY ESSRVKLERL MNFLMLPPAL ERVLWFGILA
     CLDSWLHTFT ILPLRFVKAL YILLESWAVN LGVEFRYVTG FIFKGVGRVW RRRLRASSTD
     ESSKIADPGR STSEKQENGS VERESRNRAT EPRKRHHKHR RQKSIPSALM PDDKADILKG
     LLIIATCCVL MRFDASRMYH WIRGQAAIKL YVIYNVLEVS DRLFAAIGQD VLECLFSREA
     LERRPDGRSK VFRPFGLFLL ALAYTVIHAT ALFYQVMTLN VAVNSYSNAL ITLLLSNQFV
     EIKSTVFKKF EKENLFQLLC ADVVERFQLW LMLTIIASRN LVETGAFNAL GSLSFSLGGY
     TSTGTNSTPL STPPRTSSSI LPQAFTIVPS SIIASFSQVN TYLPTLAQVL GPFLVVLGSE
     MLVDWLKHAY IGKFNNTRPA IYGRFLDILA KDYYTNAFAD QNLTRRLGLP VIPLSCLFFR
     VSVQTYQMFI TALLPQQPSS TAVEATTLSA IHSQYVPAPM PSPPPLTLRN FIPTSTAYAG
     AFFRQLLANT MPSPAQSVYI FTIVLILTGF VVLLILKLLL GMVLLAYARS RYKAMKLRES
     SSQANASSAA PADESNGTAP RGRAFAVEGS RRFGGWGVVE VNDDHRRWIY ADDPEGLRRL
     KAKEEKDKNT KEDLNMDHVQ RYEMVAKRIW
//