ID A0A401KT44_ASPAW Unreviewed; 1367 AA.
AC A0A401KT44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Canalicular multispecific organic anion transporter 2 {ECO:0000313|EMBL:GCB22484.1};
GN ORFNames=AAWM_05369 {ECO:0000313|EMBL:GCB22484.1};
OS Aspergillus awamori (Black koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=105351 {ECO:0000313|EMBL:GCB22484.1, ECO:0000313|Proteomes:UP000286921};
RN [1] {ECO:0000313|EMBL:GCB22484.1, ECO:0000313|Proteomes:UP000286921}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 58123 {ECO:0000313|EMBL:GCB22484.1,
RC ECO:0000313|Proteomes:UP000286921};
RA Kusuya Y., Shimizu M., Takahashi H., Yaguchi T.;
RT "Aspergillus awamori IFM 58123T.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB22484.1}.
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DR EMBL; BDHI01000014; GCB22484.1; -; Genomic_DNA.
DR STRING; 105351.A0A401KT44; -.
DR Proteomes; UP000286921; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR CDD; cd03244; ABCC_MRP_domain2; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223:SF269; ABC MULTIDRUG TRANSPORTER (EUROFUNG); 1.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000286921};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 802..828
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 848..867
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 947..967
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1031..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..448
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 513..746
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 809..1089
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1126..1356
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1367 AA; 150876 MW; 92082F294531EC12 CRC64;
MDRIKHIKFS PDGSMGPSIC DANGCLNCCE RCNDAKTRTL WLRHPEDINQ VIAILTSVGA
GLKILLLLLE ATEKRYILKL EYENYPPEAL AGIYNRSFFW WLNSLFRRGF SKVLGVDDLF
ALDKQLESKR LHRVLKGVVA KDKENGETSL LFACLKAFKW PILAVIPPRV MLAALNICQP
LLLERSLSFS EQPVNKSTDN IGYGLIGAYI LVYIGLGVTM GQYQHLTYRS ITMVRGAVVS
MIYEKACTLS TKDADPASSV TLMSADIERI VQGWQTMHDI WGNALEIGLA IYLLERQLGL
SCVVPVGVAI VALVGSLIAM SFVMSRQARW LEAIEKRISS TSSMLGSMKG IKMLGLQSAL
LTSVHNLRLD ELSISRKFRK LLVWNMALAW LTRIFAPIFA FGAFVGISHD RGNDAALTTS
VVYTSLSLFS LLSDPLLSLV MALMNFAGSV GSFKRIQEFL EQKEHIDPRD KSTGLSSYPL
DEKSQLALIK DTEVSMTESR STSFPSSKES LPSSVQDVVT IQNGAFGWDT TKEPLLKNLT
MSIPQGGLTL LIGPSGCGKS TLLKAFLGEV PCLHGNIQLS LDSLSFCEQT PWHMNGTIRD
CIVAMSAFDS QWYNSVIYAC ALTEDFEQLP RGDQTVIGSK GVALSGGQSQ RIALARAVYA
RKTVIILDDV FSSLDATTED HIFHHLIGKH GLLRSIDSTI IFASSSVKRA PYADHIVVLD
KSGRVIEQGS FKALDAIGGY VSSFALGLPE WGYRADLFPA SDVQIKTIEK PKIADTETEP
GVDTETQGKG GDLSIYLYYV KAIGWIPTIT FIVAIASFVF CISFPSIWVN WWASSNEAEP
GKHTGYYLGI YAMLGVIGMI CLMVGCWQMV ITMVPKSGEV FHRELLTTVL SAPMLFFSKT
DSGAILNRFS QDLQLIDMEL PIAAINTFAT LALCIAQMIL IAVASKYAAI SFPLVILIVY
LIQKMYLRTS RQLRLLDLEE KAPLFSHFTD CLSGLVTLRA FGWQQALQEK NDVLLDRSQR
PFYLLYAIQR WLTLSLDMVV AGIAVLLIVL VVVLRGSISA GYVGVALLNV IQFSQSIKLL
ITFWTNLETH IGSIHRVRTF TEEVPSEDLP TENREIPPNW PSNGEIEFKS VSAEYRASEP
VLQEVSLTIR GGEKVGICGR TGSGKTSLIM SMFRMVDITT GQILIDGLDI SQLPRQGIRS
RINGVSQSPL LMKGSVRANA DPTGCFSDEA ITHALRSVGL YSKVQEKGGL DVDIDDLFLS
HGQQQLFCLA RAILRPGNIL VLDEATSSVD TKTDEIMQRI IREKFSSHTI LTVAHKLDTI
LDYDKVVVLD AGRIVECGNP HTLLCSDKSH FSRLYASLAM DEQEESP
//
