ID A0A401L137_ASPAW Unreviewed; 782 AA.
AC A0A401L137;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Exosome complex exonuclease rrp6 {ECO:0000313|EMBL:GCB25172.1};
GN ORFNames=AAWM_08057 {ECO:0000313|EMBL:GCB25172.1};
OS Aspergillus awamori (Black koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=105351 {ECO:0000313|EMBL:GCB25172.1, ECO:0000313|Proteomes:UP000286921};
RN [1] {ECO:0000313|EMBL:GCB25172.1, ECO:0000313|Proteomes:UP000286921}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IFM 58123 {ECO:0000313|EMBL:GCB25172.1,
RC ECO:0000313|Proteomes:UP000286921};
RA Kusuya Y., Shimizu M., Takahashi H., Yaguchi T.;
RT "Aspergillus awamori IFM 58123T.";
RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB25172.1}.
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DR EMBL; BDHI01000021; GCB25172.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401L137; -.
DR STRING; 105351.A0A401L137; -.
DR Proteomes; UP000286921; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:GCB25172.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:GCB25172.1};
KW Nuclease {ECO:0000313|EMBL:GCB25172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000286921};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 450..530
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 542..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 607..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..748
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 87144 MW; 8EA51E7306CF486E CRC64;
MDSTADFGSL QQRVQSSLMQ VTRTAGQLSA EDLDFHRTSN AEVSDSLDEQ SNRLLSLTSS
ILKAATAGTD VSAPTLDEED SLEDNWRGVV DVIDALLEKA DACLDEFTGV IKKLSPSQQD
QAAAAAAKAS KKQPAKFPTI YDYGPSKIPK PQLLFERKAD NTDTAPFKPL LKTKPHAVVP
LKDSLKLSDS AVGYVNPYEK EIRAAKFPTS SYSVSPPVDY QPWESTKATF VDTLEGVKEM
LEELKAAKEI AIDLEHHDVH SYQGLVSLMQ ISTRDKDWVV DTLKPWREEL QVLNEVFTDP
NILKVLHGSS MDIIWLQRDL GLYVVGMFDT YHAACALNYP KRSLKFLLQK FVNFEADKRY
QMADWRIRPI PEGMFDYARS DTHYLLHIYD HIRNELVENS LPDNNLIDYV LEQSKKEALQ
VYERPVYDAA TGQGPGGWYD LLSRNSVVVN REQFAVFKAV HQWRDEVARE EDEGVQCVFP
KHVLFRVAHT MPLDLGTLFR TLSPVTPIVQ NRAVDLLEVI KKAKDEGADG PEWRDVYVKP
TRGTPAAPAT QPVDVPSPTP ADEANLPTVS RYEVSQFWGS VLESQEPPTV PAYSAVASAE
ALRLSLPLPP MPKTVSEARE KLAPAQPQTP KPATSAPAAK EEKKEDENKY FTVKEMGGPR
KRKAAPAETA EQSQSASSEF DTTDASSSLD TEDKPSKKQR RKEKKDKSAA QSETAAKEDG
EEEEEEAPFN YESAASVFNA NPKATSGLPS RRRYNPYAKV LDAPSGVRKQ KRETAGKAFT
FR
//
