ID A0A401NHU3_SCYTO Unreviewed; 1108 AA.
AC A0A401NHU3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=scyTo_0014173 {ECO:0000313|EMBL:GCB60442.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB60442.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB60442.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB60442.1}.
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DR EMBL; BFAA01007507; GCB60442.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NHU3; -.
DR STRING; 75743.A0A401NHU3; -.
DR OMA; LYQGNHV; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF500; GUANYLATE CYCLASE 2G; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 326..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 863..993
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1072..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 123649 MW; 680C88ABBD435C37 CRC64;
MQLAIETINS DPFFMLNCTL DFVYADSDCD PKVSINAFIS QVQKYNISAL FGPACSEAAE
ITGLLASQWN IPIFGFVDQT PMLDNFLVYD TYMNLLSPPQ RMADVLTKTL QFFGWKYIAL
IGGTARNSTW DKIDELWEMM VKMLETNFII TARAKYDTGN SALHQENLKQ IATVARIVIL
ICTPKVARSI MLEAQQLGMT SGKYVFFILH MFEVTGEMDN FWTSALLDGK DEIALNAYNS
AFLVALKFYS EYSHFNFLQE VYRRLKGAPF NSELSSETEV NSYSAYLHDA VMLYAMALQE
MLKAGKNPFD GRALIKHLKG FGKGRFYGNT LVTVVAVLLV IAFVAAAFIV FLLVKKRKSQ
NQGQDMWWKI KYEDITILKE SKKHVDALLG ATTSTKEVGS IESKTNVSSH QNYGSRDKLG
NRVVYSTIGL YQGNYVAVVH LDGSTFPDMS KQSILQELQM MRELRHENLV TFFGVCTDLP
HRCIISQYCK KGSLKGMVFL HDSPLKSHGN LQPKTCLVDS GMQVKISGFG LWEFRYGTKR
KVVVTEEVNY EELYWTAPEL LRLKEYPLNG TQKGDGEFGE DGVFGEQGEF GAQDGFGEQG
DFVEQGGFGE HGVFGEQGNF GELGVFGEHG EFGEQGEFGE QRDFGDQGVF GDQGDFGDQG
DFGEQGEFGE QGEFGAQDGF GEQCGVGEKG VFGEQGEFSE QVRFAEQGGF GEQGWFGEQG
EFGEQGEFGE QGGFGEQEII NRIINPETQL RPTLAAEKCN DQIFTLLQAC WDECADRRPN
FRSIKQALRR ASPEGEVSIL DNMVDKLEKY ATHLEEVVQE RTNQLMVEKG KTDKLLSNLL
PRFIAEQLMQ GNPVEPEFFE CVTIFFSDIV GFTNLCSSST PLQVVDMLND LYSLFDDIIM
SYDVYKVETI GDAYMVASGL PIRNGIQHAG EIATMSLHFL SAIVRFKIRH IDNVQMKLRI
GLNTGPVVAG VVGTMMPRYC LFGDTVNVAS RMESNGRPLK IHISHSTAEA LRALGGYDLV
ERGTIKVKGK GNQATYWLKG KEGFKEPLPK LDYNVEEDLK DSLETDEELA AFAASGEPGN
SASDPPEDTC TRPRGYSLEK NTVEDKTF
//
