ID A0A401NM64_SCYTO Unreviewed; 2564 AA.
AC A0A401NM64;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Laminin subunit alpha 2 {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=scyTo_0004173 {ECO:0000313|EMBL:GCB61942.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB61942.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB61942.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB61942.1}.
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DR EMBL; BFAA01001217; GCB61942.1; -; Genomic_DNA.
DR STRING; 75743.A0A401NM64; -.
DR OMA; SHSRINF; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 13.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR010307; Laminin_dom_II.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF00054; Laminin_G_1; 4.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF06008; Laminin_I; 1.
DR Pfam; PF06009; Laminin_II; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR PROSITE; PS01248; EGF_LAM_1; 4.
DR PROSITE; PS50027; EGF_LAM_2; 12.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 12..66
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 67..115
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 284..333
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 392..444
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 445..492
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 493..539
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 540..585
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 586..631
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 632..690
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 715..901
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 942..990
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 991..1048
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1049..1095
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1597..1780
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1790..1969
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1974..2158
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2207..2378
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2383..2562
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT COILED 1259..1325
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1449..1564
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 12..24
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 42..51
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 86..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 303..312
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 416..425
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 428..442
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 445..457
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 447..464
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 466..475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 493..505
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 513..522
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 558..567
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 586..598
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 588..605
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 607..616
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 632..644
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 661..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 961..970
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1019..1028
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1049..1061
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1051..1068
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1070..1079
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2131..2158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB61942.1"
SQ SEQUENCE 2564 AA; 283960 MW; A383C5D4BAFBB1E2 CRC64;
ASPYEPNPCI PCLCNLIGSL HKKCIKDIKH IKGGLLPGSC YCKTGYGGDK CDRCAFGFTG
YPNCIPCNCR IDGSLNVDPC IGPCTCKANV EGENCDQCKT GFFNLQFENY YGCDQCFCSG
VCSECEASQW TYNKVTNMFD WFLTDLQGIS KIVPKQETLD GLLKVNINKY EGSRILSRPD
YWSAPSAYLG HKLTAYGGKL IFIISADSTG QLSRNQKSQI FFEGNGILIT NGVEGIELDP
LSKQTKMIVL RPENFVIHPT LSPSCAPGYR RVNGTLYGGI CVPCVCYGHS NYCDDVTGEC
LNCQHDTTGP FCAKCRPGFY GDPTRGTASD CHPCSCPLLI PTNNFSPTCH LDARGEIICD
RCPPGYAGSR CDRCSEGFFG RPNKPGGLCQ PCQCNGNLDL SAPGSCNSLT GECLHCIEGI
SGQFCDQCAE GFFGDAVVAR NCRSCECHVN GSIAELCDKQ TGQCQCKHNV AGRRCDHCLS
GTYLHSSRGC VPCNCNSFGS KSFDCDNKGQ CRCQPGVAGQ KCDRCALGFY NFQEGGCDPC
KCAHVGNHCD SETGQCVCPP NTMGEKCDQC AANFWGHNFV SGCQHCDCTI VGSLNLQCDD
VTGCCFCRPG YTGEKCDRCR AGYWNYPQCR HCDCGVAGTE GQTCDEAAIC SCAEYNGQCN
CKVNVEGISC DRCKTGAFAL YSSNPHGCSS CYCSGVTTQC TEAKGLIRRR LMLNPDQTVL
EIVSKFNNRK TTSGVFHQHP EIVANVDAVI KHLLYEPFYW KLPEQFEGEK LKAYGGKLRY
AIYFEAREEV GQSTYEPQII MRGGPTREMI IVRHVSAPQI GQLTRHEVEL TEHDWKYDNS
PDGRSVSRKD FMDVLYDIDS ILIKASYGTF MRQTRISEIS MEVAEATDSY FLAEHAQQIE
QCFCPEGYSG LSCQDCGPGY YRTPLRSTIR GPRPVTWSCV QCQCNGHSDI CDYKTSICQN
CRDNTAGVHC EVCAPGYYGT VRGSPNDCRP CACPLQISSN NFSPTCVMEG HNAYRCDACQ
EGYEGQYCDR CLSGYYGNPR IEGSSCIQCE CDPIGSLPVP CDKATGQCNC KPGMKGWNCD
SCTEWHVREG TKCISCDDEC TGLLLNDLEH LNQLITRLNL SGPFPPPYKV LYRYENVSQE
LKYLMSPQRA PERLLQLADS NLDTLITEMD ELLNRTTKVS ADGEQTDKDT EKTHKRAMEL
EKSIGYTVLS SQDLKEKTKK LNETLRIKDG VTEKNLQHMQ KDVETMMAEM RRKSFDKHEE
MAEDELDAAS ALLEKVKKMF ADPHKTTRAL KDEVMNKLTD YKDKFNEAQE LLKEAREKIK
ETNRLSAVNQ KNMTALEKRR QAVEAGKKDT EYVLNEGHNL VAEAKRLLEE IALGLDELER
QKHLEPPISE LKDKIDALAA GIHDEKLPKL VLRAEDHAAV LNDSSGILDG ILAEAKNLSF
NATAAFKAYT NIKDKIDEAE KVAKEAKDTA HQAVRLLYAI PKDASTKIQA AKDKAKQAND
TANAVLAEIK DLNQNLLGLQ DNCSKLKDDV AKANAAVDMP AKTISDADMK VKELEEKTDK
LLNKLKPIKN LQDTLGKNIS HIKELINQAR KHANSIKVSV SSGGDCIRTY RPDIKKGTYN
SIVLNVKTSE LENLLFYLGS AKYTDFLAIE MRKGKVNFLW DVGSGVGRVE YPDLIINDQY
WYRIEASRFR RNGTVSVRAL DGPRASIVPT TYSAVSPEGY TILDVDEKAY LFVGGLTGEV
KKSDVVKTTT FSGCMGETSL DRKPIGLWNY RDRQGECKGC VVSPQPTDTE GTVQFDGEGY
ASVGRPTRWN PNVSAIVFKF RTFTSDALLM YLATKDLRDF MSVELADGRI KMSYDLGSGP
VNVTSRGRHN DGKWKSFTLS RILKQANISI RDTINNKEEN LVVVSPGTNF GLNLKADEKI
YFGGLPILQN LRPEVNLKKY SGCLRDIEIS QSPYNLLSGT DYLGLTKGCI LENVYTVSFH
KPGFVELQPH SLNIGTEISL SFSTKNETGM ILYGSGKTPT QLKRKRRQTG QVYYAVFLNK
GRLEVHIATG TREHRRVTIK PESGVFNDGK EHSVRLQRSK GLLVVQVNEE RAQRQRLPND
LPLSIKRLFV GGVPASFQVS QLRSITPFEG CIWNLVINSV PLDFAQPVSF EHADIGRCPT
LKPSKPLPDE PETVEITVKP ITELSKIPTP APNTCAVDIP PVALLRAKHF GLSRNSHVAM
EFDDTKVKTR LIIEFEIQTE AESGLVFYMA RINHADFATI QIIDGMAHFS YDLGSGNANT
VVQKKINDGE WHKVRIVRDR KRATVTIGLN VATTVTPKNA DILDVVGMIY IGGLPKNYTT
RRIGRVVYSI NACIRNFKLN NKTFDLNNPT SSLDVGTCFL NSQRGNYFDG TGFAKAVARY
RVGTDLRIEF DFRTAQKDAV LLGISSQRVD GLGIELVGGK IFVYVDNGAG IFAVAFESPH
FNGLCQGQWH NVVVNKIKYR LELIVDGEKV ESRSPSVTST ATDTNDPIFV GGYPDDMKQL
ALTINTPFKG CIRNLKLTKA TQTLEIDFSK AVELQGVQPL TCPA
//
