ID A0A401NMK1_SCYTO Unreviewed; 696 AA.
AC A0A401NMK1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0009461 {ECO:0000313|EMBL:GCB62074.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB62074.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB62074.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB62074.1}.
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DR EMBL; BFAA01003862; GCB62074.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NMK1; -.
DR STRING; 75743.A0A401NMK1; -.
DR OMA; EEHFVAW; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT DOMAIN 114..243
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 256..530
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 549..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 78700 MW; FEF9CBABA9948515 CRC64;
MVRLMWPDLQ NDCEAGGGQK KMFDGSRRAR NIWDGVMLEV SGQPSPVILH SFTQLDPDLP
LTESAAQEIG EETEDGAIYT ITLRKIQSHQ AASKGQRRLG VDSESAMNLY ETCKVRTIKA
GTLEKLVEYL VSAFKGNDTT YVTIFLCTYR AFASTKQVLD LLLNRYGNPH QVNGDVSKLT
AEDRVQLKST ISSILGAWLD QYSEDFRKPP DYSCLRHLYT YIHQMFPGSD LQRRAHILLG
TFQRHKEPEA DPDVTEADHS SCTFAMVEEN GFEDRKPDFL SFCANVVAEQ FTLMDARDKK
GKEHLAPTIR ATVTQFNRVT NCVIATCLSD KTLKPQQRAK VIERWIEVAR ECRIFKNFSS
LRAILSALQC NSVHRLKKSW DEVSRENIRI FQELSEIFSD DNNHSLSREL LIKEGTSKFA
TLDINPKRAQ KRQQHQKEMG VMQGTIPYLG TFLTDLVMLD TAVKDHLDGG LINFEKRRKE
FEVIAQIKLL QSACNNYSFT PDHRFVEWFR SVERLTEAES YNLSCEIEPL AESASNTLKA
KKNSGIIKRW SDRQTPTADT PGTGAQSRSC EQLKYGPYLG GGDTTDSVSV TSAGSSNSDV
EEINVSFISE SPDSQEKKQV DDCCIIRVSL DVDNGNMYKS ILLMTSVMIG IGPAPRTTKR
GRLHHKLGRF SEVQQRKLMQ VLEQCTNYLL EDLVKC
//