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Database: UniProt
Entry: A0A401NMK1_SCYTO
LinkDB: A0A401NMK1_SCYTO
Original site: A0A401NMK1_SCYTO 
ID   A0A401NMK1_SCYTO        Unreviewed;       696 AA.
AC   A0A401NMK1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=scyTo_0009461 {ECO:0000313|EMBL:GCB62074.1};
OS   Scyliorhinus torazame (Cloudy catshark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB62074.1, ECO:0000313|Proteomes:UP000288216};
RN   [1] {ECO:0000313|EMBL:GCB62074.1, ECO:0000313|Proteomes:UP000288216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB62074.1}.
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DR   EMBL; BFAA01003862; GCB62074.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401NMK1; -.
DR   STRING; 75743.A0A401NMK1; -.
DR   OMA; EEHFVAW; -.
DR   Proteomes; UP000288216; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF35; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT   DOMAIN          114..243
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          256..530
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          549..568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   696 AA;  78700 MW;  FEF9CBABA9948515 CRC64;
     MVRLMWPDLQ NDCEAGGGQK KMFDGSRRAR NIWDGVMLEV SGQPSPVILH SFTQLDPDLP
     LTESAAQEIG EETEDGAIYT ITLRKIQSHQ AASKGQRRLG VDSESAMNLY ETCKVRTIKA
     GTLEKLVEYL VSAFKGNDTT YVTIFLCTYR AFASTKQVLD LLLNRYGNPH QVNGDVSKLT
     AEDRVQLKST ISSILGAWLD QYSEDFRKPP DYSCLRHLYT YIHQMFPGSD LQRRAHILLG
     TFQRHKEPEA DPDVTEADHS SCTFAMVEEN GFEDRKPDFL SFCANVVAEQ FTLMDARDKK
     GKEHLAPTIR ATVTQFNRVT NCVIATCLSD KTLKPQQRAK VIERWIEVAR ECRIFKNFSS
     LRAILSALQC NSVHRLKKSW DEVSRENIRI FQELSEIFSD DNNHSLSREL LIKEGTSKFA
     TLDINPKRAQ KRQQHQKEMG VMQGTIPYLG TFLTDLVMLD TAVKDHLDGG LINFEKRRKE
     FEVIAQIKLL QSACNNYSFT PDHRFVEWFR SVERLTEAES YNLSCEIEPL AESASNTLKA
     KKNSGIIKRW SDRQTPTADT PGTGAQSRSC EQLKYGPYLG GGDTTDSVSV TSAGSSNSDV
     EEINVSFISE SPDSQEKKQV DDCCIIRVSL DVDNGNMYKS ILLMTSVMIG IGPAPRTTKR
     GRLHHKLGRF SEVQQRKLMQ VLEQCTNYLL EDLVKC
//
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