ID A0A401NP19_SCYTO Unreviewed; 695 AA.
AC A0A401NP19;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Protein-tyrosine-phosphatase {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0004274 {ECO:0000313|EMBL:GCB62587.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB62587.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB62587.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB62587.1}.
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DR EMBL; BFAA01001256; GCB62587.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NP19; -.
DR STRING; 75743.A0A401NP19; -.
DR OMA; QEGCKAP; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF499; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE EPSILON; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 136..394
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 314..385
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 426..684
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 600..675
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 695 AA; 79220 MW; 42D946E9F69A6E17 CRC64;
MPGKPNAWTA NDNAKSAMMS NTSDETNSNF TTSPNSTKSP NLKDSYIPVY VIVPLAVAIL
IAAVIYFRNT VLRRRKKEVV IGGEKKIPNG ILEEQEQQTV MLLTRSPTVS KRYPPIPVEA
LEHEVQKRSA DEGKLFREEF NSLPIGTSVG CCEAANKEEN KDKNRYPNIL PGDNYRVTLT
AIDGVPGSDY INASYVDGFK VKNKFIAAQG PKEETVSDFW RMIWEQKSAA IVMLTNVKEK
KEEKCFKYWP DQGLWTYGAI RVSVEDVTVL VDYTIRKFTI QNQRAGNKSP RLVTQLHFTS
WPDFGVPFAP IGMLKFLKKV KAVNPSHSGP IVVHCSAGVG RTGTFIVIDA MIDMMYAEQK
LDVFGFVSRI RGQRSQLVQT DMQYSFIYQA LLEHYLYGDT ELDVTSLEKH IQKLHSKAGQ
FDITGLEEEF NKLITVRIRK ENMRTGNKPV NMKKARVLQI IPYDFNRVVL PRKRGQEFSD
YINASYIDGY RQKDYFVATQ GPLPHTVEDF WRMVWDCKSH TIVMLTELRE REQEKCSQYW
PTEGSATFGS YTIEMKNDHI SDAFSVRDLT ITNTTESKSR IVRQFHFHGW PEIGIPVEGK
GMIDLIAAVQ RQQQQSGNHP IIVHCSAGAG RTGTFIALSN ILERVKAEGL LDVFQTVKSL
RMQRPHMVQT LEQYDFCYQV VQDFLDIHSD YANFK
//
