ID A0A401NP50_SCYTO Unreviewed; 377 AA.
AC A0A401NP50;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Splicing factor 45 {ECO:0000256|PIRNR:PIRNR031066};
DE AltName: Full=RNA-binding motif protein 17 {ECO:0000256|PIRNR:PIRNR031066};
GN ORFNames=scyTo_0007261 {ECO:0000313|EMBL:GCB62617.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB62617.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB62617.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- FUNCTION: Splice factor that binds to the single-stranded 3'AG at the
CC exon/intron border and promotes its utilization in the second catalytic
CC step. Involved in the regulation of alternative splicing and the
CC utilization of cryptic splice sites. {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBUNIT: Associates with the spliceosome.
CC {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR031066}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB62617.1}.
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DR EMBL; BFAA01002592; GCB62617.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NP50; -.
DR STRING; 75743.A0A401NP50; -.
DR OMA; FDKHRTS; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd12647; RRM_UHM_SPF45; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040052; RBM17.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034653; SPF45_RRM.
DR PANTHER; PTHR13288:SF8; SPLICING FACTOR 45; 1.
DR PANTHER; PTHR13288; SPLICING FACTOR 45 SPF45; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF031066; Splicing_factor_SPF45; 2.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR031066};
KW mRNA splicing {ECO:0000256|PIRNR:PIRNR031066};
KW Nucleus {ECO:0000256|PIRNR:PIRNR031066};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR031066};
KW Spliceosome {ECO:0000256|PIRNR:PIRNR031066}.
FT DOMAIN 207..247
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 59..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 377 AA; 42437 MW; 0B1CCBDFD574A7D2 CRC64;
MSLYDDLGVE TSDSKTEGWS KNFKLLQSQL QVKKATLTQT KTQRSKQSTV LAPVIDLKRG
SSGDDRQIID TPPHIASGLK DPVPSGFSTG EVLIPLADEY DPMYPNDYEK VVKRQREDRQ
RQRELERQKE IEEREKRRKE RHEQPSGLPR RPDPESDEDD EEREKERRKR SMGGAAIAPP
SSLVEKDKEQ RPRSPPGPTN SFIANMGGTV AHKIMQKYGF REGQGLGKHE QGLSTALSVE
KTSKRGGKII VGDSAEKVEM PVTTKKSEAN PLTEILKNPT KVVLLRNMVG AGEVDDDLEG
ETKEECEKYG KVSKCVIFEI PGAPDDEAVR IFVEFERVES AIKAVVDLNT RYFGGRVVQA
CFYNLDKFRQ LDLGDLY
//
