ID A0A401NQW5_SCYTO Unreviewed; 2537 AA.
AC A0A401NQW5;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=K Homology domain-containing protein {ECO:0000259|SMART:SM00322};
GN ORFNames=scyTo_0007363 {ECO:0000313|EMBL:GCB63239.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB63239.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB63239.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB63239.1}.
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DR EMBL; BFAA01002650; GCB63239.1; -; Genomic_DNA.
DR STRING; 75743.A0A401NQW5; -.
DR OMA; EDCEMQK; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22503; KH-I_ANKHD1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 9.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR047374; KH-I_ANKHD1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF7; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1 ISOFORM X1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 8.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00013; KH_1; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 25.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT REPEAT 231..263
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 264..296
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 297..329
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 331..363
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 364..396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 397..429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 430..462
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 494..526
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 527..559
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 560..592
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 594..626
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1009..1041
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1042..1074
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1076..1108
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1109..1141
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1144..1176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1178..1210
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1211..1243
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1246..1278
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1279..1311
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 1655..1725
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 958..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1406..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1486..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1522..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1577..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1862..1899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1954..2015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2237..2271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2297..2384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 738..810
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 967..984
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1420..1454
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1543..1564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1863..1899
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1962..1976
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1977..2015
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2243..2271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2304..2355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2366..2384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2537 AA; 270338 MW; E05623E6B71B265B CRC64;
MQNEVIAENR ALDTMTDGFE DEIDSVTAAV STKVRILEPT PGDRLDFKLA VLSGSEEDEV
SEVESFILDQ EDLDNPMLKT ASELLLSSAA DGTDLRTVDP ETQARLEALL EAAGIGKLST
ADGKAFADPE VLRRLTSSVS CALDEAAAAL TRMRAENTLN AGQADNRSLA EACSDGDVNA
VRKLLDEGRS VNEHTEEGES LLCLACSAGY YELAQVLLAV HANVEDRGIK GDITPLMAAA
SGGYVDIVKL LLAHDADVNA QSSTGNTALT YACAGGFVDV VKVLLKAGAN IEDHNENGHT
PLMEAASAGH VEVARVLLEY GAGINTHSNE FKESALTLAC YKGHLEMVRF LLEAGADQEH
KTDEMHTALM EACMDGHVEV ARLLLDSGAQ VNMPADSFES PLTLAACGGH VELAALLIER
GANLEEVNDE GYTPLMEASR EGHEEMVALL LAQGANINAQ TEETQETALT LACCGGFLEV
ADFLIKAGAD IELGCSTPLM EAAQEGHLEL VKYLLAAGAN VHATTATGDT ALTYACENGH
TDVADVLLQA GADLEHESEG GRTPLMKAAR AGHLCTVQFL ISKGANVNRA TANNDHTVVS
LACAGGHLAV VELLLAHGAD PTHRLKDGST MLIEAAKGGH TNVVSYLLDY PNNILPVPGS
DVAQLTPPSH DQSQVPRVPV QALAMVVPPQ EPDQSPVNVG ATLSVINKGT SKQKSSPLQV
AEQDVQPFHE YQPLECIVEE TEGKLTELGQ RINAIEKAQL KSLELIQGDT LTKDKIEELK
KSREEQVQKK KKILKELQKV ERELQLKTQQ QFTKEYLEAK GQQQTLQLQQ QQQQCPQGGL
FPQVGTDDCL PEEDFSKLPQ VDTILHRDGQ QQPPATQMGF IPIQPLATQV SPNFTSSVYP
INNVPDLQRV IVNQPLLGQA QLAGLGQGLL AQAPDGLMVA TPAQTLTDTL DDIMAAVSSR
MPSGPNPPSH TTTPPTPQPR TQTPSPVVSP SSMLPLYPSV EIDAQTESNH DTALTLACAG
GHEELVSVLI ARGANIEHRD KKGFTPLILA ATAGHVGVVE ILLDKGADIE AQSERTKDTP
LSLACSGGRQ EVVELLLARG ANKEHRNVSD YTPLSLAASG GYVNIIKILL NAGAEINSRT
GSKLGISPLM LAAMNGHVAS VKLLLDMGSD INAQIETNRN TALTLACFQG RAEVVSLLLD
RKANVEHRAK TGLTPLMEAA SGGYAEVGRV LLDKGADVNA PPVPSSRDTA LTIAADKGHY
KFCELLINRG AHIDVRNKKG NTPLWLAANG GHFDVVQLLV QAGADVDAAD NRKITPLMAA
FRKGHVKVVQ YLVKEVNQFP SDIECMRYIA TITDKELLKK CHQCMETIVK AKDQQAAEAN
KNASILLKEL DLEKSREESR KLALAAKREK RKEKRKKKKE EQKRKQEEEE ARVKENSEKQ
QTPEKDRFED EEVVPIEPPS ATTTTTIGIS ATSATFTNAY GKKRANVVTT PSTNRKNKKN
KTKDSSQSVQ IILEDQHMSI AQQKADKNKI NGEPRGGGVG GNSDSDNVDS TDCNSECSSG
GKSQDLNVIA DFHNFSDQKL YPPRNEKSNT SISETQNHPR LHDVTNETNS NSLSTTHKST
SLPLSSPNGK MNLTSPKRGQ KREDGWKEVV RRVALTRSKK LSVPASVVSR IMGRGGCNIT
AIQDVTGAHI DVDKQKDKNG ERMITIRGGT ESTRHAVQLI NALIQDPAKE LEDLIPRNHI
KSVTANTRMG STAATTTAST TTAGHRITVS MMSSSATASL STSSSTSLQS INKPGKNIVS
NNMRPTFSVS LPLAYSHPQL AHALLAAQTI QQIRHPRLPM AHFGGTFSPS PNTWGPFPVR
PVSPGSANSS PKHNTTRLNQ GSNTIHPNTG NSAPINSPSL AVSSPTFTTP SLCVTSSPTP
SSVRKQLFTS VNKTNIMISV TSAVTCNSCS LPTNSTVSVS NGQPPTPPPP PPLVQPSQQS
MSLTKNEPFT TSTAKEEVTT TEQPAGSQCA HSNVCNSSSV SSNPGAIGIQ PTSSLPSILP
QISCRSSSDI RPSLPKPYIS NTDHGLVAPS SLASTRPVTM SACPNVQTNN TLPQLAAASP
QVSHRIQPGA SFYPLVQQEP QSVFVPNPVP MVSTQDPMKQ HGVPSPMQLS SALGMLNVSQ
LHPNPGSKSL PPNFGSAALF SPFNSFFDNT QVSANHVWGS CPLPSRPTQD PTFSGHTNYM
GSSVLGQLDA VLPHDNSKAP GFRPPSQRVT SSPTGMSAMD PSGNAISSSS TPLTSFAPSM
AGTQVYVQGP APVGMPAPSF SRQHFSPHPW SSTTAPATCE SPPSVSSGAS SPLSAASAPP
SLGQPKSSNA NQDRKVPPPI GTERSARIRQ TGSMTPLSTM VGSNLTTPVG QGGIWSFGVS
NNSDGISGWS QGVMGGHLMH QSISDPASFS QHQTLERDDT GIVAPSNTFH QPVPSNFMDY
NKQGLPLSMY GNAMIPPHPQ MADGPGAPLF NGLHATDPAW NPMIKVVANS SDNADPQQVW
PGTWAPHIGN VHLNHVN
//
