ID A0A401NU56_SCYTO Unreviewed; 964 AA.
AC A0A401NU56;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=NACHT domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0013332 {ECO:0000313|EMBL:GCB64372.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB64372.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB64372.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB64372.1}.
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DR EMBL; BFAA01006761; GCB64372.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NU56; -.
DR STRING; 75743.A0A401NU56; -.
DR OMA; FLQRRWK; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR Gene3D; 1.10.533.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041210; NLRC5_atypical_Card.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47189; MHC CLASS II TRANSACTIVATOR; 1.
DR PANTHER; PTHR47189:SF1; MHC CLASS II TRANSACTIVATOR; 1.
DR Pfam; PF18461; Atypical_Card; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 23..97
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 302..437
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 131..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 964 AA; 108188 MW; D11E4E5B3443A704 CRC64;
MRANGAVEFP LWPRLDWLVT GMCTSGIKEV LESNHGQLVE CLSLEADYVL ENVKGILDKE
ELNLVRSQRT KEGKISELLK TLMTKDNDTC KKFIDTVIII MPCNSFPMCL ENMLMTAGDN
DTEGLLHQQQ NEANSVSTPY SEEESRVPDI GRKRKAGQVA TTEVKQSRKG NHYKAAAVKN
SSTSTIWNPD PEEMDNTSSQ TGEEYLNLPA ISDFAEDYKS LMIQSISQKY EANMAKEDQM
KQVTLDQTFR SLTMKDGNVA KLKERIDASR DDVLSSPGLE ENQDSVANLA EFLSRKRASH
CRVHILLGKA GTGKTKLMHK ICYEWTRGAV SQFQYVFLFE FRQLNLIKKT IDLKSMLFDF
FLQPERKPHS VFRFIIGNPK KVLILFDGFD EFAGKAAVRN LVVSDDPIAP LSVGQLFSSL
YNGKLLPGCT ILITSRPKDI LCLPLDVVGQ VGEVSGFNQC KIKEYAGRFF KDSEHNRQAI
CHLLKNSKIL NMCYIPAMCW VVFLCLEHLL SRSHLEPKLP HTMTQFYIEM LTVFLSKGTN
SKEANGNTEN RLLNKHREEI QGLCNLARKG LQESKSVFYL RDLLSEKVTD FASSYGFLTT
FEVKTIDQNQ ENGHAFVHLT FQEFLAALHQ MIDSTVTDQM LKRRFYLKSK WTSKNDMKNE
FTDAVHIFLS GLASKGCKQF LGILSSKNEV WVQNKQKAIL QTLRKLATTN LTGPKIIELC
HCVYETQDHD LAREVAAHLK SKFELRNFRL TPVDLTVLTF VINSGANCIC LDIGGCAMEL
ECVTVLGTCK NIEVLVFKSR KYEDKFAATL SEVIPKISSL KKLILTSCSI SAKGVAHLSP
ALKKCHHLEE INLQDNELAD AGIAVLVDSL PQMGSLRKIE LGGNNITVCG VLTIANAIST
CLNILDIHVS DGGNIATVRF FASSATSPMN RSSRPLSPSM ECEGSHEPLV RKLRYWIYCT
LASQ
//