ID A0A401NU71_SCYTO Unreviewed; 773 AA.
AC A0A401NU71;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Phosphatidylinositol 3-kinase regulatory subunit alpha {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0007532 {ECO:0000313|EMBL:GCB64407.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB64407.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB64407.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB64407.1}.
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DR EMBL; BFAA01002749; GCB64407.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NU71; -.
DR STRING; 75743.A0A401NU71; -.
DR OMA; GNENTEX; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd12924; iSH2_PIK3R1; 1.
DR CDD; cd04388; RhoGAP_p85; 1.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR044124; ISH2_PIK3R1.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 46..122
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 155..344
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 380..475
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 673..767
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 123..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 496..523
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 561..609
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 127..144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 773 AA; 88768 MW; 2AFFF5EB2CA7D8E8 CRC64;
MRCWHQVGTA LRPIISDTAY FEGNGTKLFK SSLTKQGLST IGKMSADGYQ YRALYEYKKE
REEDIDLHTG DILIVTKNTL LALGFSEGAE AKPDEIGWLT GLNETTQERG DFPGTYVEFH
GFRKISPPTP KPRPPRPLPV APNPLRPEDS DLQASVLPDL TEQFSPPDIA PTLLVKLVEA
IEKTGIENTN LYRTSGSYGS TELKQLLDYD ATPMDIEQLD LQSLADVLRQ YLQELPNPVI
PASIHSDLVS IAQEVLNTEE CAQLLRRAIR SHNVPHQYWL TLHYLIKHFC KLCQSSGKNN
LSARTLAEIF SPLLFRQQAA NSDTNPEYHI KIIEVLIASE CQETQPTPAS APALPPKPPK
PTPVTNNGIN SNMSLQDAEW YWGDISREEV NEKLRDTADG TFLVRDASTK MHGDYTLTLR
KGGNNKLIKI FHRDGKYGFS DPLTFNSVVE LINHYRHESL AQYNPKLDVK LLYPVSKFQQ
DQVVKEDNID AVGKKLHEYH TQYQEKSREY DRLYEECTRT SQEIQMKRTA IEAFNETIKI
FEEQCQTQER YSKEYIEKFR REGNEKEIQR IMVNYEKLKS RISEIVDSKR RLEEDLKKQA
ADYREIDKRM NSIKPDLIQL RKTRDQYLTW LTQKGVRPKK INEWLGIKNE NAEDQYSMVD
DDEDLPHHDD RTWNVGSINR TRAESLLRGK RDGTFLVRES SKPGCYACSV VVDGDVKHCV
INKTPTGYGF AEPYNLYNSL RELVLHYQHT SLVQHNDSLN VTLAHPVYAN QRR
//