ID   A0A401NV46_SCYTO        Unreviewed;       656 AA.
AC   A0A401NV46;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=AMP deaminase {ECO:0000256|ARBA:ARBA00012775};
DE            EC=3.5.4.6 {ECO:0000256|ARBA:ARBA00012775};
GN   ORFNames=scyTo_0014805 {ECO:0000313|EMBL:GCB64730.1};
OS   Scyliorhinus torazame (Cloudy catshark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB64730.1, ECO:0000313|Proteomes:UP000288216};
RN   [1] {ECO:0000313|EMBL:GCB64730.1, ECO:0000313|Proteomes:UP000288216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1. {ECO:0000256|ARBA:ARBA00004955}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB64730.1}.
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DR   EMBL; BFAA01008090; GCB64730.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401NV46; -.
DR   STRING; 75743.A0A401NV46; -.
DR   OMA; RYWISHI; -.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000288216; Unassembled WGS sequence.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 3.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR006329; AMPD.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR11359; AMP DEAMINASE; 1.
DR   PANTHER; PTHR11359:SF1; AMP DEAMINASE 1; 1.
DR   Pfam; PF19326; AMP_deaminase; 2.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000288216}.
SQ   SEQUENCE   656 AA;  76045 MW;  EF837DE9CF8EF2FC CRC64;
     MSKVKKPEID EEARILAEKV FAHDAKDEDE RDEISPFDMA DDCPIGQLEM QHHLIDRKSK
     ESTSKRLKII MRAKEIGTSV PVIQVPEATQ STVSAVHMVQ PSYADVPEFQ RVTITGDYAS
     GVTVEDFEVA CKGLYKALTI REKYMRLSFQ RFCRTTAHFL RTMDSEKWRE GNEVHPVFTQ
     STKAGKDPFS PKDLPENLGY VCKMKDGVIY IYANDESVKR NEPKDLPYPD LPTFIDDMNF
     LIALIAQGPV KTYAHRRLKF LNSKFNLHEM LNEMEELKEV KSNPHRDFYN VRKVDTHIHA
     AACMNQKHLL RFIKNSSKLD PDRVVSTCKD QKLTLKELFK KLKLNAYDLT VDSLDVHAEV
     ASDLEDAKYQ HAEPRLSIYG RSPDEWTKLA SWFIMHRVYS PKMKWMIQIP RIYDIFRAKN
     FIPHFGKMLE NIFMPIFEAT VNPQDNVKLS IFLKHITGFD SVDDESKHSG HMFCIKSPKP
     EEWNMPKNPS YSYYLCYMYI NIMVLNNLRN PVLQYLYFLT QLPIALSPLS NNSLFLEYAK
     NPLPEYLRKG LMISLSTDDP MQFHYTKEPL MEEYAIAAQV FKLSTCDICE IARNSVLQSG
     FSEQEKAHFL GPNYRQEGPA GNCIQKTNVA QIRMAYRYET LCYELNLIKE GLKVLE
//