ID A0A401NV94_SCYTO Unreviewed; 974 AA.
AC A0A401NV94;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
DE Flags: Fragment;
GN ORFNames=scyTo_0007585 {ECO:0000313|EMBL:GCB64789.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB64789.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB64789.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB64789.1}.
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DR EMBL; BFAA01002786; GCB64789.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NV94; -.
DR STRING; 75743.A0A401NV94; -.
DR OMA; WPEHKRT; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR HAMAP; MF_01113; DNApol_IV; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SMART; SM00734; ZnF_Rad18; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
DR PROSITE; PS51908; ZF_UBZ4; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 136..399
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT DOMAIN 878..908
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 728..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..974
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..110
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 946..963
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB64789.1"
SQ SEQUENCE 974 AA; 109816 MW; 0562EDB466D3CBD4 CRC64;
SCLIANVESL GLECMIREDK GKIRLIREIN MEHTAKETAD SSAPSDGILS RMALNDNKAG
MEGVDKEKIN KIIMEASKGS RFYENERKKE QQVNQRIEKM LQQKAHITEQ QLTKKQYQVE
RLATELEKSR DLSRTIVHID MDAFYAAVEV KDAPELKDKP MAVGSMSMLS TSNYHARKYG
VRAAMPGFIA KKLCPNLVII PANFDKYRAV SKEVQEILVD YDPNFLPMSL DEAYLDLTEH
LHQRQNWPEH KRTYYCHGEG VTNVKENMDD LEPSCEDLKN ISPILFEDSP PILSQQGSVQ
CEIQQTDLHL QSIDKELHQQ QKEAIVFGVT AEEAVREMRF RVEQKTKLTA SAGIAPNMML
SKVCSDMNKP NGQYRIPADS IAVMDFIKNL PIRKVPGIGK VTEKLLNALG ITTCTELYQQ
GALLSLLFSE SSWYHFLEIS LGLSETHLER DGDRKSMSTE TTFSEISKAA EQYSLCRDLC
HDLEEDLQKE GLRGKTVTLK LKNVNFEVKT RACTVPTPVS KEEEIFAVAH ELLKTEISNV
HPRPLRLRLM GVRVSGFVHQ DEKRSHQKSI IKFLHTGKSE STSKSDNIDV KDQEELRETF
KRDGFFNKKC KQNNGQSFFN QVLAKKQQER CKSAVTIPGS NVAEGSGLTR ELKATSNSSI
CFKKQGINKQ VDEWPCVTRS SQVSEIGEPN TSTISYISTK KSGLDNDLES KIINLKSDQL
NNEQKGMKYK ERPSETYRNM TGGTENSSFD WESSVKNKAC CIGQSGDQAH LKEMLKHHMA
LPSNAAKTLE LTKDKDTLIE EISDHNSLLY NKLSDKSTNT TQGEKQFGQQ ELSAGMLDLP
PFTQLDPLIQ RTHYMQQQSK LTRSSQERHP SYSEEPAGLV CPICNIKQGT TDLSLFNRHV
DICLNQGVIQ ELTERPARPT MSECFSNGIG LTGLEKPSSS SIVRTKRIGS TAQQPTTKKA
RCSGSKNTID RFLK
//
