ID A0A401NZ52_SCYTO Unreviewed; 522 AA.
AC A0A401NZ52;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Signal transducing adapter molecule 2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0013542 {ECO:0000313|EMBL:GCB66134.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB66134.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB66134.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB66134.1}.
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DR EMBL; BFAA01006960; GCB66134.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401NZ52; -.
DR STRING; 75743.A0A401NZ52; -.
DR OMA; YMPAGIS; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21390; GAT_STAM2; 1.
DR CDD; cd11820; SH3_STAM; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF1; SIGNAL TRANSDUCING ADAPTER MOLECULE 2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 4..134
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 197..256
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 132..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 57558 MW; 1248CC396B8B2D25 CRC64;
MEKATNEHNT SEDWTLIMDI CDHIGTTPNG PKDCLKAIMK RVNHKNPHVA MKALTLLGAC
VSNCGKIFHL EICSRDFTNE IGNLLSLYNK AHPKVCEKLK ALMVEWVEVF QKDPQLSLVA
ATIKALKEDG VTFPSTSSQS QSTSNPSKNG TTAISRNTED VALAKAIELS LQEQKQQQTE
TKSLYPATEN PSNSHRTELR MVRALYDFEA VEDNELTFKA GEIITILDDS DPNWWRGETK
RGVGLFPSNF VSTSLNAEPE PEKVLVAEET TVQEVQPSEP EPVYIDEEKM DQALQLLQNA
IPTDQQPDSA ELLHLEDVCQ QMGPIIDEKL EEIDRKHSEL SELNVKVLEA LELYNKLMND
VPMYSSMYSK PQTQSQAQAQ AYYAQQSATV PMQVYPGQSQ SATYMPAGIS QVAASHGYSL
GPEQLGALRS LPPTMNSATA SQSSQIPYMS TGPPQAYMNQ TANLQVTTGP AAPYTSQAGL
NNDMSAYQNT TISGPPAASY PMASQAQHIP QQHSNYFQQP LL
//
