ID   A0A401NZU8_SCYTO        Unreviewed;       658 AA.
AC   A0A401NZU8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN   ORFNames=scyTo_0010101 {ECO:0000313|EMBL:GCB66432.1};
OS   Scyliorhinus torazame (Cloudy catshark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB66432.1, ECO:0000313|Proteomes:UP000288216};
RN   [1] {ECO:0000313|EMBL:GCB66432.1, ECO:0000313|Proteomes:UP000288216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC         dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC         ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC         ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB66432.1}.
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DR   EMBL; BFAA01004287; GCB66432.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401NZU8; -.
DR   STRING; 75743.A0A401NZU8; -.
DR   OMA; NITRECS; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000288216; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.1280.180; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR042572; Carn_acyl_trans_N.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          52..641
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        372
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   658 AA;  74302 MW;  E44ECD8DD85A4422 CRC64;
     MAVLRVASTL NKLGRAGTVT LIRNSSSSSP DLDYLHKSIV PTNHFQKSLP RLPIPKLQDT
     MQRYLTAQRP LLDDDQYRRT EQLAQDFKKG IGNQLHEELV TQDKRNKHTS YISGPWFDMY
     LSAREPVVLN YNPFMSFHPD PNPANNSQLI RATNMTVSVL RFMKTLRAGL LEPEIFHLNP
     AKSDTSQFKN IIRFVPASIS WYGAYMVNAY PLDMSQYYRL FNSTRIPKPI QDELLTDDSA
     KHLLVMRNGH FYTFDVIDQD GRITKASEIQ AHFKYILSDP RPPPEFCLGY LTSENRDTWT
     LLRQSLLEAG NAQVLNKIDT AIFCICLDDM TVKDHLELSH NMLHGNGLNR WFDKSFSIIL
     TKDGNAAINF EHSWGDGVAV LRLMNETFKD TTQRPAISAT TLPAAVNSSQ AVQKLDFKLN
     DVLKSGISSS RQNFDAAVST LSIDALEFRK GGKEFLKKQN LSPDAVAQLS FQMGFLRQYD
     KTVATYESCS TAAFKHGRTE TIRPATIYTK KCCEAFVKES SKHSTSDLRT MIGECSKYHG
     QLTREAAMAQ GFDRHLFALR YLAKSKGMAL PELFQDPSYI QINHNILSTS TLTSPAIQLG
     GFAPVVPDGF GVGYGIHDHW IGYIISSYAA RDVKEFLKCV NKSLDDIFDV LEGRPIRI
//