ID   A0A401P071_SCYTO        Unreviewed;       641 AA.
AC   A0A401P071;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=Aryl hydrocarbon receptor {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=scyTo_0012027 {ECO:0000313|EMBL:GCB66562.1};
OS   Scyliorhinus torazame (Cloudy catshark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB66562.1, ECO:0000313|Proteomes:UP000288216};
RN   [1] {ECO:0000313|EMBL:GCB66562.1, ECO:0000313|Proteomes:UP000288216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB66562.1}.
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DR   EMBL; BFAA01005678; GCB66562.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401P071; -.
DR   STRING; 75743.A0A401P071; -.
DR   OMA; PLNFCTS; -.
DR   Proteomes; UP000288216; Unassembled WGS sequence.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030522; P:intracellular receptor signaling pathway; IEA:UniProt.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   GO; GO:0006805; P:xenobiotic metabolic process; IEA:InterPro.
DR   CDD; cd11435; bHLH-PAS_AhRR; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR039091; AHR/AHRR.
DR   InterPro; IPR039092; AHRR_bHLH.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR10649; ARYL HYDROCARBON RECEPTOR; 1.
DR   PANTHER; PTHR10649:SF3; ARYL HYDROCARBON RECEPTOR REPRESSOR; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT   DOMAIN          3..56
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          98..161
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          159..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        360..382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:GCB66562.1"
SQ   SEQUENCE   641 AA;  72374 MW;  425B87224D87844E CRC64;
     KSAPTSVKSN PSKRHRDRLN AELDHLASLL PFPPDIISKL DKLSVLRLSV SYLRVKNFFQ
     AFQETELQKE SHQFINHDMR DSQPTLLTGN WRSEGELMLD ALDGFVLLVS ADGKIFYVSP
     TIIDYLGFHQ TDVMHQSVYD FIHVDDRQEF QRQLHWAMNP PQQAPGQEPP GQGGSGDEYQ
     GPFKAQDPKI LPPEFSPFLN RCFISRLRCL LDSTSGFLTM QFQGRLKYLQ GQRKKTGSGV
     NLPPQLGLFC IAVPLLFPPI SELKLKGLLL KSKHRLDLSP TPLDAKGKPA AGWSDAELRA
     KSGCHYLHFT DMLYCAENQI RLMDNGEKGV TVFRVLTKDG QWVWLQTNGH LPYRNKSPEC
     ATMPKEELKD TERSKEERLR NQSNPNQSDS ANRLVYSNCT ESSQQLKHLY EQHLGKGGRE
     DKYEPIRNDG GINQNEPLNF CTSFPRAPKV TITDDLWGPE YSRGALNSQP PRTVERISSV
     PGRVAKPFCG RSRLLSEPQL RGGAQAPSFQ NIAQSFRGIG EEMHQSQSYG TLHYTDLEGY
     PPEPCKSEDV GSVTDFVAPR PKDHPVGYCN STEMFLGVHI KSEYNPDPHS ELDQPLASPG
     HQWTDAGEMG KKIAVNFLPQ MTSSTESLDC NEERWVYFIL E
//