ID A0A401P4A9_SCYTO Unreviewed; 671 AA.
AC A0A401P4A9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=scyTo_0008150 {ECO:0000313|EMBL:GCB67947.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB67947.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB67947.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB67947.1}.
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DR EMBL; BFAA01003066; GCB67947.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401P4A9; -.
DR STRING; 75743.A0A401P4A9; -.
DR OMA; CIAQKTH; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006553; P:lysine metabolic process; IEA:UniProt.
DR Gene3D; 1.10.1870.10; Domain 3, Saccharopine reductase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032095; Sacchrp_dh-like_C.
DR InterPro; IPR005097; Sacchrp_dh_NADP.
DR PANTHER; PTHR11133:SF25; ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11133; SACCHAROPINE DEHYDROGENASE; 1.
DR Pfam; PF16653; Sacchrp_dh_C; 1.
DR Pfam; PF03435; Sacchrp_dh_NADP; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT DOMAIN 228..344
FT /note="Saccharopine dehydrogenase NADP binding"
FT /evidence="ECO:0000259|Pfam:PF03435"
FT DOMAIN 348..661
FT /note="Saccharopine dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16653"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB67947.1"
SQ SEQUENCE 671 AA; 74214 MW; E823555D48A1E544 CRC64;
QSKIYCTVLS RHHHVVRKSD GKYDPVDYQH HPKLYTSRFS TDIAPYTTCL VNGIYWELDT
PRLLTHSDAQ NLLTSAKDCD SASDGCPELP HRFLAICDIS ADTGGSIEFM TECTSIDMPF
CMYDAEQQGI HDSLEGNGIL MCSIDNLPAQ LPIEATEYFG DKLCPYLWEM LTSDAKQPLE
KENGLTPIIR NAVIASNGSL TPKFKYIQKL RANRESAQIR SMSAKGRVLL LGSGYVSGPV
LNYITRDTDI EVTVASVLED QLEKLISNYN HTTPVTLDIM KDGDKLSSLV KSHDLVISLL
PGVFHPIVMK ECIEQKVNMV TASYQTPEME EMHQSALDAG ITILNEVGLD PGIDHMLAMK
RIDEAKEQGS TIESFVSFCG GLPAPECSDN PLGYKFSWSP SGALINTIRP AIYIKDGKVI
DIAAGGAVLD NANPMAFFPG FNLEGIPNRD SLKYGKSYGI QSARTLLRGT LRFKGYANTM
KGFNKLGLIN PDPNVLLSPE APPITWRELM CNLVGIAPSS SFASLQEAVY EKIERDDHRM
STVMWLGILE DNPVQKERNI LDTFAKHIEP KLSYAPGERD LVVLRNDVGI RHTSGQLETK
HDSLVVYGDV GGFSAMAKTV GYPCAIGAEM ILDGEISTKG MICPLTKDIY QPILDRIRTE
GFMQQKHLSH F
//
