ID A0A401P6N1_SCYTO Unreviewed; 757 AA.
AC A0A401P6N1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=T-box domain-containing protein {ECO:0000259|PROSITE:PS50252};
DE Flags: Fragment;
GN ORFNames=scyTo_0005360 {ECO:0000313|EMBL:GCB68784.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB68784.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB68784.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB68784.1}.
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DR EMBL; BFAA01001659; GCB68784.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401P6N1; -.
DR STRING; 75743.A0A401P6N1; -.
DR OMA; EQCKPER; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20188; T-box_TBX2_3-like; 1.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR022582; TBX2/3_TAD.
DR InterPro; IPR048387; TBX2_3_RD.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR PANTHER; PTHR11267:SF82; T-BOX TRANSCRIPTION FACTOR TBX2; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF12598; TBX; 1.
DR Pfam; PF20627; TBX2-3_RD; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01283; TBOX_1; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 150..332
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 325..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 397..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 448..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB68784.1"
SQ SEQUENCE 757 AA; 81944 MW; 6AAA4A26E2C7871C CRC64;
EGGRQTHTHR LHIHTCSSRR WCRRSGEGFS QQESVPHPHP PLLLPNAPMR EPVLAAITMA
YHPFHAHRAA DFPMSTFLAA QPSFFPALAL PPSGAAALSL PGALGKPLTE QNMAEAAIRV
SALGHQSAHL RPLKSLEPED EVEDDPKVNL EAKDLWDQFH KVGTEMVITK SGRRMFPPFK
VRVNGLDKKA KYILLMDIVA ADDCRYKFHN SRWMVAGKAD PEMPKRMYIH PDSPATGEQW
MAKAVTFHKL KLTNNISDKH GFVSVATILN SMHKYQPRFH VVRANDILKL PYSTFRTYVF
PETEFIAVTA YQNDKITQLK IDNNPFAKGF RDTGNGRREK RKQLSLPSLR VYEDPCKGDR
DAGDSDASSS DLPMARESRR SPSAGDPVSL QFKQTPKDDK SGADSEPELE TREEHSAAIT
SSSRGAASRI NTPPAEHAAG DTPQRPRPGS APERKKESLE GGRDTESSSS HRSSEREKGE
RGRKEEAKKD AECLRKDTYS PLMVQTEGPS HLNAGHLQSL AFSGLHSQHF FNPLNVGQPL
FIHPGQFAVP PGAFSAMATG MGHLLASVSG AGSLENATIA SAPGSAGAGA HFPFHLSQHV
LASQGIPMTT FGGLFPYPYT YMAAAAAAAA LPNTSGAPSS LHRHPFLSGG RPRLRFNPYP
IPVSIPASTN LLTTAVPSAL GGPDSKLCSS RASSPVSVGL ASEISHKSSG GSLRTGASSL
SPKANAKEAI NELQNIQRLV SGLENSREIP PAGDCPK
//
