ID A0A401P7A3_SCYTO Unreviewed; 537 AA.
AC A0A401P7A3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 13-SEP-2023, entry version 15.
DE RecName: Full=Suppressor of cytokine signaling 6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0000982 {ECO:0000313|EMBL:GCB69002.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB69002.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB69002.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB69002.1}.
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DR EMBL; BFAA01000202; GCB69002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401P7A3; -.
DR STRING; 75743.A0A401P7A3; -.
DR OMA; TPWPLRS; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0040008; P:regulation of growth; IEA:InterPro.
DR CDD; cd10387; SH2_SOCS6; 1.
DR CDD; cd03740; SOCS_SOCS6; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035865; SOCS6_SH2.
DR InterPro; IPR037345; SOCS6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 386..493
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 488..537
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 50..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 537 AA; 60089 MW; CA0B4B7A9A410723 CRC64;
MKKISLKTIK KSFNLNKGKD ESEFVVVQPP SLVNDFGKED SLFSCYGKDL AGNDLNKADE
DDKGSKNKAK GEGLMGTLKR RLSAKQKQKV KGNAPSVNLV EDDRFSSSST PTSINDLKAQ
RPLRSTSLRG HHYSPTPWPL RSASSEETCI KMEVKVKALV HNNSPNQALN GVRKEFHDMQ
ADHVFQEQSS TIKEIEPQNG HSHLNIDESC HVPVVIGLMP QNYIQYTMPL EEGMFPMDGS
RTCCLDNPLP MDIASVPSHI CSSSLQIDDS QMVPDLVVAS DIFLDPPVNG LLIGTTGVML
QNSSSNHVDI PPLSPLLPPI PNQMQLTFPG FGGTSAHVAE RVRHHLNFDP NSAPGVGRVY
DSVQNNGPMV VTSLTEELKK LAKQGWYWGP ITRWEAEEKL ANVPDGSFLV RDSSDDRYLL
SLSFRSQGKT LHTRIEHSNG RFSFYEQPDV EGHTSIVELI EHSIKDSENG AFCYSRSRLP
GSATYPVRLT NPVSRFMQVR SLQYLCRFVI RQYTRIDLIQ KLPLPNKMKD YLQEKHY
//
