ID A0A401P8R7_SCYTO Unreviewed; 603 AA.
AC A0A401P8R7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=PR domain zinc finger protein 8 {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0012433 {ECO:0000313|EMBL:GCB69483.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB69483.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB69483.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB69483.1}.
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DR EMBL; BFAA01006003; GCB69483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401P8R7; -.
DR STRING; 75743.A0A401P8R7; -.
DR OMA; FVYTTAF; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19192; PR-SET_PRDM8; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044402; PRDM8_PR/SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16516; AGAP007109-PA; 1.
DR PANTHER; PTHR16516:SF7; PR DOMAIN ZINC FINGER PROTEIN 8; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF13894; zf-C2H2_4; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 49..164
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 539..567
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 580..603
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 272..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 603 AA; 67875 MW; E65BC588347BADD2 CRC64;
MLHFYSLANQ NIWAGEEKRG EDLSGFTPSA STMEDPNIHK VFWESDASRA VQQCLTNIFT
SVYTTCDIPE NAIFGPCILS HTSLYDSIAF IALKSADKRT VPYIFRVDTS AANSSSEGLM
WLRLVQSARD KEEQNLEAYV KNGQLFYRSL RRIDKDEELL VWYGKELLEL LLLSNVRAQA
KMNGSSPYTC LDCSQRFQCE YPFLAHLRFR CQKRLGCIVS DENGKISGDR NYQIAVGSSV
KFSRSERQSA FSNVENTKTT TDFHNLARDM ENPRENVRNR RETESLNENK RKCEEAEEKN
DNILHTVKAA DRSLAIPRES LLCPSQQFRG GYFNLRENGR LMAPSSPEST DIKRSAFFEV
KRTSLHLKQT PKDHVPGLDS KNGAAPNASS SEKPTEIKSV LTETQVPSCL DNIAMGSAFR
SVSQLCGTEE RKSAFSQPAR SFTQLSPLLV SQKVMPGLEC HPGVGDSGRL YQANALAAKL
QSADVNGNCN VQGGLAKQSP FVYATAFWPK ASGPIQLQVP SALTLLPPSF TSFCLPAQNW
CAKCNASFRM TSDLVYHMRS HHKKEYAMEP LVKRRREDKL KCPICNESFR ERHHLSRHMT
SHN
//
