ID A0A401PAZ4_SCYTO Unreviewed; 1086 AA.
AC A0A401PAZ4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=scyTo_0008538 {ECO:0000313|EMBL:GCB70281.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB70281.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB70281.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Photoreceptor outer segment membrane
CC {ECO:0000256|ARBA:ARBA00004451}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004451}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB70281.1}.
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DR EMBL; BFAA01003293; GCB70281.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PAZ4; -.
DR STRING; 75743.A0A401PAZ4; -.
DR OMA; HTELHHI; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd14043; PK_GC-2D; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF477; GUANYLATE CYCLASE D; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07701; HNOBA; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00228; PDZ; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vision {ECO:0000256|ARBA:ARBA00023305};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 393..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 463..737
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 809..852
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 864..950
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 996..1082
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT COILED 746..773
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1086 AA; 121576 MW; 4EE9074F987C073B CRC64;
MAAKLAVDRI NKGGFLHHRY KLDYVVLQDD CQTSKALSNF VEFEKHASVF LGPANPGYCE
AASLMGKNWN KGIFSWACVN FQLDNANSYP TFARTLLPPV RVLYNVMKYF LWAHIGIISS
NENIWVDTAN KVANALRYNG LPVGIVTSMG FTDEDIVKTL MKIRNVPDLR IIIMCMHSVL
IGGEEQAVFL QKAHEMGLTD GRFVFVPYDT LLYSLPHKNV SYSVLRNNSQ LRSAYDAVLT
VTMASEEMDF YEALIKAQEN GEIATSQQPE QVSPLFGTIY NGVYFIAKTM ESVQRDGRHI
SGITLANYTK NLKFVGFNQK IETNSRGEGI VNYVILDTDG RSHHLSPTYT IDMATETVEG
SGKTIHFPGG SPPHADSSCW FDPNATCTGG IELTVVLLAF GFIIALALCG LGLTYVIRRR
IQQIQMVKGP NKIIMTLEDL TFINPQLSKK KITLDELSDG RSISERKSLK SGMHSLSGKS
LTAVNHENSN VALYEGDWVW LKKFNPGSLC DVQKATTKIL KKMRDLRNEN VNPFLGFLCD
SGVLAIATEH CSRGSLHDLL RNDDVKLDWM FKSSLLLDLI KGMKYLHHRD FAHGRLKSQN
CLVDGRFVLK IADYGYLELL ETQKASREKP PPEELFWTAP EFLRDSELSK KATMKGDSYS
FAIILQEVVV RGAPYCMLGL SPGEIIRKVK KPPPMCRPTV SPDQAPLECI QLMKQCWSEL
PERRPTFNEI FDRFKTINKG KKTNIIDSML RMLEQYSSNL EDLIRERTDE LEVEKQKTEK
LLSQMLPPSV AEALKMGGNV EPEYFDQVTV YFSDIVGFTT ISALSEPIQV IDLLNDLYTL
FDAVLGNHDV YKNFLHAFTC HEKIISVRKE AHESLGMTVS GGLLSKGWDL PIYVTHVLPD
GCLGNDGRIK NGDILLDING IELTGMTQSE AVSIIKHSAA SSSVVFKALE LRVAEKDNVN
SQMPLNANQN SLPEDDWSPS WNMWLGLPRY LYWCKDIGLR RNTSGSLGFS IVGGYEENYG
SQPFFIKSIV YGLPAYNDGR LRCGDMILAV NGRSTSGISH PCLVKMLKEA RGKVMLTVAS
WPGSHL
//
