ID A0A401PBF8_SCYTO Unreviewed; 521 AA.
AC A0A401PBF8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Receptor ligand binding region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0005680 {ECO:0000313|EMBL:GCB70454.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB70454.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB70454.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB70454.1}.
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DR EMBL; BFAA01001808; GCB70454.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PBF8; -.
DR STRING; 75743.A0A401PBF8; -.
DR OMA; KECRPGQ; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd06364; PBP1_CaSR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF0; VOMERONASAL 2, RECEPTOR 23-RELATED; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 14..414
FT /note="Receptor ligand binding region"
FT /evidence="ECO:0000259|Pfam:PF01094"
FT DOMAIN 456..494
FT /note="GPCR family 3 nine cysteines"
FT /evidence="ECO:0000259|Pfam:PF07562"
SQ SEQUENCE 521 AA; 58076 MW; BB56CFF2EA8A118B CRC64;
MPFNLRAFRW VQLMIFAIEE INNDPSLLPN ITLGYKIYDS CATPALALRA ALTILNGQEE
NVTLSRCNGG SPVHALIADA GSTQSITIAR TAGLFGIPMI SYFSSCICLS NKKEFPTFFR
TIPSDYFQVA AFVQLVKHFG WTWLAAFGSD DDYGHLGISA FVEEVTKIGA CVAFAEYLPK
FNDKGKILHQ VELIKKTKVK VILVFAPEIE LNFLVEELVR QNVTGLQWLA SEAWSTAALL
STAANSEIMG GTLGLAIRRA DIPGIKQFLV RLHPSNYPGN EYIKQLWEAV FHCTWTSHND
TENARLGPLK HVCTGQEDLK VAQNAFTDET QLRVSYNTYR AVYAVAHSIH NMLQCQNGQG
PFVNETCPDI SKLKPWQVLH YLKKVKFTTA FGDEVRFDVN GDPRATYDLL NWQRVPNGNM
KYIKVGQYDA SVGTDNQLVI EKEGIVWSGG QKMVIEAKCS ESCLPGTRKG ARTGEPICCY
DCLPCAEGEI SNQTALHNNA IPLNLNFENK NFYEISVQMK E
//
