ID A0A401PHJ0_SCYTO Unreviewed; 1150 AA.
AC A0A401PHJ0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Helicase SKI2W {ECO:0008006|Google:ProtNLM};
GN ORFNames=scyTo_0002073 {ECO:0000313|EMBL:GCB72592.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB72592.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB72592.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB72592.1}.
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DR EMBL; BFAA01000498; GCB72592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PHJ0; -.
DR STRING; 75743.A0A401PHJ0; -.
DR OMA; CGSDITR; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0006401; P:RNA catabolic process; IEA:InterPro.
DR CDD; cd18027; DEXHc_SKIV2L; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 3.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 273..429
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 495..660
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 135..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1150 AA; 130467 MW; B0081740B4B470EA CRC64;
MEQERLEVPP KDPDDLPLSI LEVGCSGKFE LITQPATKNG YIFPLATLPH GLPPYALDLI
TEAEQHFLSD PSKLPLHHFE NSQKVWPREV CVDSLYHTDV TPVHSTLKVE RNQTTGELLG
YKEVRLDDTG LSIKNSLSLQ RPPGPPTQTV RGSSTNYPFW PGGMDEPSLD MIKSMGEFEE
SIDFEKDLLT VPPGWKKGLN FKKTEHKVAP GLLSLTNLIG AMDDFNLGGS SDEEDEKKRK
TAEAKQPLPR TNSLEDLVLQ WPFEPDVFQK QAILRLETHD SVFVAAHTSA GKTVVAEYAI
ALSQKHMTRT IYTSPIKALS NQKFRDFKNT FKDVGLLTGD VQLHPEASCL IMTTEILRSM
LYNGSDAIRD LEWVIFDEVH YVNDAERGVV WEEVLIMLPD HVNLILLSAT VPNTLEFADW
IGRIKQKKIY VISTMKRPVP LEHHLYTGNS QKTQSELFLL VDAQGNFLTK GLPIVAFTFS
RNRCDENANM LTTVDLTSTV EKSEIHIFFQ KCISRLKGTD RELPQVLQMV GLLKRGIGVH
HSGILPILKE VVEMLFTRGL VKILFATETF AMGVNMPART VVFDTIRKHD GTNFRDLTPG
EYIQMAGRAG RRGLDTTGMV IILCKAGVHE MADLHKMMLG KPTQLQSQFR LTYTMILNLL
RVEALRVEDM MKRSFSEFHT RKDVKIYEQQ IQELTKKLSS MEEVECIGQL SDLEHYYNTV
RELLCTRDAL QKRIMESTSG FKALSVGRVL VVKTQRHKNA LGVILQVATD STNRTFTTLV
LSESRQEETE KEVEALPMAP TPDQLLTNKL FLPEGPCGHT VEKLTTKQIG SVTVKTLRIN
ADKIIDDFKK RQIPRFRNDP PGPSVTTATQ ELLRLAESHP DGIACLDPIS DLQLKDLDLV
DDYTRARRLE DSLSKFTCFH SPRFSTEYAR MQERMMIKDE LDRLRFLVSD RSLMLLPEYE
QRVNVLKTLK YIDESCAVQL KGRVACEISN HELIVTEMVF ENVLTDLHPE EIVALLSCLV
FQQKTQVEPE LNEVLRKGIE RIRGVAERIA TLQRECSLQE SIEDFVDQFK FGLVEVVYEW
AKGLPFAEIT RLTDVQEGII VRCIQRLNET CRDVRNAARI IGDPTLNAKM EQASNLIKRD
IVFAASLYTQ
//
