ID A0A401PJF3_SCYTO Unreviewed; 450 AA.
AC A0A401PJF3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=TGF-beta family profile domain-containing protein {ECO:0000259|PROSITE:PS51362};
GN ORFNames=scyTo_0002436 {ECO:0000313|EMBL:GCB73252.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB73252.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB73252.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB73252.1}.
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DR EMBL; BFAA01000612; GCB73252.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PJF3; -.
DR STRING; 75743.A0A401PJF3; -.
DR OMA; VRACCVP; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13767; TGF_beta_BMP9_like; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR PANTHER; PTHR11848:SF283; TGF-BETA FAMILY PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 338..450
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 450 AA; 50260 MW; 16880B80A58D5F74 CRC64;
MSRMCSNKSA SDHPPSLAMP CCAWFVLVST TLGCLLQVAM CKPLAGWDQA SGPEGVQSYE
LEGAPDEDAG FDFGAFLESM KDEFLRSLNL SDVPGHDPAK VEAPPQFMID LYNKFATDRS
SMPSSNIVRS FRNEDTTSSP AGEDQVRRHI LVFNVSIPRH EEVTMAELRL YTFLERDRRM
YEGVDRVVTV YDVEEAEEGP QGVSVPPQLA LLVSKQIVGK DSGWEAFDVT DAIKRWFKSS
KATHRLEVRI QSGQEGEAVE LADLDTNPSP QDRNVPLLVV FSNDRSHGRR ESGDEMKEMI
VHEQEVVLEE LADGSSSHGH VEDLLKAQAM LSYDSSSRTR RNARGDYCKR SPLHVDFSEI
GWNSWIIAPK SYEAYECRGV CYFPLTDHVS PTKHAIIQTL VNRSNPKKAA RACCVPTKLD
PISVLYKDDA GVVTYKYKYE GMVVAECGCR
//
