ID A0A401PLD1_SCYTO Unreviewed; 80 AA.
AC A0A401PLD1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=Liver-expressed antimicrobial peptide 2 {ECO:0000256|ARBA:ARBA00020494};
GN ORFNames=scyTo_0003011 {ECO:0000313|EMBL:GCB73929.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB73929.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB73929.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- FUNCTION: Has an antimicrobial activity.
CC {ECO:0000256|ARBA:ARBA00002585}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the LEAP2 family.
CC {ECO:0000256|ARBA:ARBA00008047}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB73929.1}.
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DR EMBL; BFAA01000787; GCB73929.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PLD1; -.
DR OMA; SRRMTPF; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR Gene3D; 4.10.40.50; -; 1.
DR InterPro; IPR009955; LEAP-2.
DR PANTHER; PTHR21007; LIVER EXPRESSED ANTIMICROBIAL PEPTIDE 2; 1.
DR PANTHER; PTHR21007:SF1; LIVER-EXPRESSED ANTIMICROBIAL PEPTIDE 2; 1.
DR Pfam; PF07359; LEAP-2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..80
FT /note="Liver-expressed antimicrobial peptide 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019510723"
SQ SEQUENCE 80 AA; 9126 MW; 55E33FE9D8DE1DA0 CRC64;
MHAQLIKSFA TICIASILLS SQADCAAIGQ VETVLHRVRR MTPLWRWITY RPLGSSCRSD
DECGTKYCRK KRCSLIVHED
//
