ID   A0A401PMH4_SCYTO        Unreviewed;       888 AA.
AC   A0A401PMH4;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN   ORFNames=scyTo_0003370 {ECO:0000313|EMBL:GCB74281.1};
OS   Scyliorhinus torazame (Cloudy catshark).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB74281.1, ECO:0000313|Proteomes:UP000288216};
RN   [1] {ECO:0000313|EMBL:GCB74281.1, ECO:0000313|Proteomes:UP000288216}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA   Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA   Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA   Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA   Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT   "Shark genomes provide insights into elasmobranch evolution and the origin
RT   of vertebrates.";
RL   Nat. Ecol. Evol. 2:1761-1771(2018).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GCB74281.1}.
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DR   EMBL; BFAA01000908; GCB74281.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A401PMH4; -.
DR   STRING; 75743.A0A401PMH4; -.
DR   OMA; ANASHIF; -.
DR   Proteomes; UP000288216; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 2.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010457; IgC2-like_lig-bd.
DR   PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23036:SF83; INTERLEUKIN-6 RECEPTOR SUBUNIT BETA; 1.
DR   Pfam; PF09067; EpoR_lig-bind; 1.
DR   Pfam; PF00041; fn3; 2.
DR   Pfam; PF06328; Lep_receptor_Ig; 1.
DR   SMART; SM00060; FN3; 5.
DR   SUPFAM; SSF49265; Fibronectin type III; 4.
DR   PROSITE; PS50853; FN3; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..888
FT                   /note="Fibronectin type-III domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5019137295"
FT   TRANSMEM        612..632
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          217..315
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          320..418
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          514..606
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   REGION          851..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   888 AA;  100505 MW;  E8C8A7B9604E257B CRC64;
     MLSTENTWAW VMFSISACVI QGELPRLCHY VDPVPGVFQL LSNVSLSCTL REDCLKSLDA
     NASHIFWKMN DTQISQEQYY FNATVSRVTF QAVKGYLTCH INMKGAANIL HRFAIEVGFP
     PDKPKHISCV SYWRENITCF WDQGRETNLK TNFTLIRKWG PSQNDSCNTL ENTCFFKFPR
     LHISTNLTII VMAENALGKA QSDPFVLDSW HTWKTDPPQN VIVHSILGQS RSLFVTWNKP
     TEKPPALVLF YGLQYQTTGS SNWTRVTEEK INTTSFVIKN LKPFTNYIVA VRCIGESQFY
     WSDWSSKETG LTPEAKPCKG PELWRRIKSL DSQGKRNVHL LWKALNRSEA NGIILGYRVW
     YAKKRDPTVM LQCNTTYLNY SLFLANEAYI ITLVAYNSAG DSPKATLIVP AINQTALSAV
     QYVKVIPQDD QLFVQWKTSR PPENGYVIEW CLILDTSPFA GPLHWVHKGN TSEMAWLKEN
     VEQYKRYNIS VYSVYDDGPD NPFSVPAYLQ QDVPAEGPDI LAPDLKDTET TIKWREIPVE
     KRRGFITNYT IFYKSAKGEN AVTVNSTVHN YTLKSLQKNT DYVLYVMAST VKGGINSSIH
     FRTDSLGQDD TVVIVVPVLV CFLLIVNVLM ICSSNKHRIK KHIWPEVADP AGSTLADWFH
     EHQYENDQTP KLLNPWNDFN TDFSTVEVLC LSDECLLRSS RKDEASLLHS ETEVECSFTM
     SPPPDSTSNG EKTSLLQSMN TVMCAVLEEG YKSQIPDISR SLSKQPLLSN TSEKSTSDFE
     TEINTADGAE ENWCPQTTDE NGVFQQINKT SADLKNSLSS TDSQIAPCLD SSNDPVFDNC
     CKVDKNVQED TGTVDPNLQS PQQDNQPTNP VQTYITVELL ELMLNNEM
//