ID A0A401PND8_SCYTO Unreviewed; 658 AA.
AC A0A401PND8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE RecName: Full=GBD/FH3 domain-containing protein {ECO:0000259|PROSITE:PS51232};
GN ORFNames=scyTo_0003720 {ECO:0000313|EMBL:GCB74629.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB74629.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB74629.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB74629.1}.
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DR EMBL; BFAA01001042; GCB74629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PND8; -.
DR STRING; 75743.A0A401PND8; -.
DR OMA; AMRRANW; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF6; PROTEIN DIAPHANOUS; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216}.
FT DOMAIN 91..457
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 504..531
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..36
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..556
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 658 AA; 75796 MW; AF1E9CBB59DCB853 CRC64;
MDGQQPQTGS ESPPRSKDRS SSKKKPPEDD PRNKTKLNLN IKTLADDVRD RLTSFRKSTT
KKEKPYIQHP TDSQIAMCDL PLAQPVFEEC FMNLSEKEIL DLFEKMMEDM NLNEDRKVPL
RGKDLMTKRE MVVQYISATA KSGGLRNSKH ESTLSSQEYV HELRSGITDD KLLNCLESLR
VSLTSNPVSW VNNFGHEGLG LMLDALEKLL DKKQQEIIDK RNQHKLIQCL KAFMNNKFGL
QRILGDERSL LLLARAIDPK QTNMMIEIVK ILSAICIVGE ENILDKILEA MTTAAEQNNR
ERFAPIVEGL DNHEALQLQV ACMQLINALV TSPDDLDFRI HLRNEFLRCG LKKLLPVLKE
KENEELDIQL KVFDENKEED FIEVSHRLED IRSEMDDMNE VYHLLSNMVK DTAAENYFLS
MLQHLLLIRN DYYIRPQYYK IIEECISQIV LHRNGVDPDF EYRKRLEVDF SHLIDQCVDK
VKVEESEKMA SEYSKKFDEE FTARQEAQAE NQKKDEKIKE LETKLHQLEA ERKAAPVPSG
APPPPPPPPP PPGALAILPH GLQPKKQYNP EAAMRRANWS KIGPQEMTET CFWIKAKEEQ
FESPDLFAKL MLSFATQTKV AEELLGCLAG DFIPPLLASR RSMREHSKHP HRSHWNFT
//
