ID A0A401PPV8_SCYTO Unreviewed; 579 AA.
AC A0A401PPV8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Dynein axonemal assembly factor 1 {ECO:0000256|ARBA:ARBA00024429, ECO:0000256|RuleBase:RU364076};
DE Flags: Fragment;
GN ORFNames=scyTo_0018968 {ECO:0000313|EMBL:GCB75159.1};
OS Scyliorhinus torazame (Cloudy catshark).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC Scyliorhinus.
OX NCBI_TaxID=75743 {ECO:0000313|EMBL:GCB75159.1, ECO:0000313|Proteomes:UP000288216};
RN [1] {ECO:0000313|EMBL:GCB75159.1, ECO:0000313|Proteomes:UP000288216}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=30297745; DOI=.1038/s41559-018-0673-5;
RA Hara Y, Yamaguchi K, Onimaru K, Kadota M, Koyanagi M, Keeley SD, Tatsumi K,
RA Tanaka K, Motone F, Kageyama Y, Nozu R, Adachi N, Nishimura O, Nakagawa R,
RA Tanegashima C, Kiyatake I, Matsumoto R, Murakumo K, Nishida K, Terakita A,
RA Kuratani S, Sato K, Hyodo S Kuraku.S.;
RT "Shark genomes provide insights into elasmobranch evolution and the origin
RT of vertebrates.";
RL Nat. Ecol. Evol. 2:1761-1771(2018).
CC -!- FUNCTION: Cilium-specific protein required for the stability of the
CC ciliary architecture. Plays a role in cytoplasmic preassembly of dynein
CC arms. Involved in regulation of microtubule-based cilia and actin-based
CC brush border microvilli. {ECO:0000256|RuleBase:RU364076}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU364076}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family.
CC {ECO:0000256|ARBA:ARBA00006453, ECO:0000256|RuleBase:RU364076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GCB75159.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BFAA01013692; GCB75159.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A401PPV8; -.
DR STRING; 75743.A0A401PPV8; -.
DR Proteomes; UP000288216; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070840; F:dynein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF19; DYNEIN AXONEMAL ASSEMBLY FACTOR 1; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR SMART; SM00365; LRR_SD22; 4.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|RuleBase:RU364076};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU364076};
KW Leucine-rich repeat {ECO:0000256|RuleBase:RU364076};
KW Reference proteome {ECO:0000313|Proteomes:UP000288216};
KW Repeat {ECO:0000256|RuleBase:RU364076}.
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 547..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..579
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:GCB75159.1"
SQ SEQUENCE 579 AA; 61153 MW; C2A792D4A2BFA331 CRC64;
SVITAVTLSA KGDGEVQTET EDHQALSVTE QPSFSEESKP VRSERESKLQ RDERLPDQEG
AKSVEINELD STKHKEETKK GLGSISVIPA VTLSPVGDEI VQLEIEDRQA NQLLSCSEGT
EAVRSEGTEA VSSEGTGAVS SEGTEAVRSE GTEAVSSEGT GAVSSEGTGA VSSEGTGAVS
SEGTGAVSSE GTGAVSSEGT EAVSSEGTGA VSSEGTEAVS SEGTGAVSSE GTGAVSSEGT
EAVSSEGTGA VSSEGTEAVR SEGTGAVSSE GTEAVRSEGT EAVSSEGTGA VSSEGTAAVS
GEGTAAVSSE GTAAVSGEGT AAVSSEGTEA VSSEGTKTVR REGESKLQKS DQLNDQERTK
SREIHELKSR KPQEKAKKDS GPRMTKQFLR QHCKQQKLYQ TPYLNDTLYL HFKGFSCIEN
LEEYTGLRCL WLECNGLLTI ENLDAQTELR CLFLHQNLIH KIENLEPLQK LDSINLSNNY
IKTIENISCL PELKTLQLAH NQLCTVKDIE HLKQCPSLSV LDLSHNKLDD PDIITVFKAM
PNLQQNGQQE MGKERGWGLE EEKGVRREKE SDEAALFEY
//
